Dai, Kun; Peng, Xiaoqiang; Zhuang, Wei; Yang, Pengpeng; Jiao, Pengfei; Wu, Jinglan; Ying, Hanjie published the artcile< Mass transfer process and separation mechanism of four 5′-ribonucleotides on a strong acid cation exchange resin>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is 5′-ribonucleotides; Homogeneous surface diffusion model; Ion exchange chromatography; Mass transfer process; Physical adsorption; Separation mechanism.
5′-ribonucleotides including AMP (AMP), cytidine 5′-monophsphate (CMP), GMP (GMP) and UMP (UMP) have been widely used in the food and pharmaceutical industries. This work focused on the assessment of mass transfer process and separation mechanism of four 5′-ribonucleotides and counter-ion Na+ on the strong cation exchange resin NH-1. The intraparticle diffusion was determined as the rate-limiting step for the mass transfer of AMP, CMP, GMP, and Na+ on the resin NH-1 through the Boyd model. Meanwhile, a homogeneous surface diffusion model (HSDM) combing ion exchange and phys. adsorption was proposed and tested against adsorption kinetic data in the batch adsorption systems. The fixed-bed film-surface diffusion model based on the HSDM was then developed and successfully predicted the concentration profiles of 5′-ribonucleotides and the change of pH at the outlet of the fixed-bed in the dynamic adsorption and separation process. Finally, the separation mechanism of 5′-ribonucleotides was presented combining model prediction and exptl. results. The separation of UMP, GMP and CMP were mainly based on their differences in isoelec. points, while that of AMP and CMP were lied with the discrepancy of their phys. adsorption binding capacity with the resin NH-1.
Journal of Chromatography A published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem