In 2022,Chen, Chen; Ding, Jie; Liu, Liying; Huang, Yujie; Zhu, Bolin published an article in Advanced Synthesis & Catalysis. The title of the article was 《Palladium-Catalyzed Domino Cyclization/Phosphorylation of gem-Dibromoolefins with P(O)H Compounds: Synthesis of Phosphorylated Heteroaromatics》.Computed Properties of C6H12O3 The author mentioned the following in the article:
We presented a palladium-catalyzed domino cyclization/phosphorylation of gem-dibromoolefins, which utilize H-phosphinates and secondary phosphine oxides as the phosphine sources, resp. A variety of phosphorylated heteroaromatics were obtained in moderate to good yields with wide functional group compatibility. This one-pot reaction enables multiple bond-forming events including C-X (X = O, N, S) and C-P bonds using easily available starting materials. Moreover, this protocol can be easily applied to large-scale preparation and late-stage functionalization.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Computed Properties of C6H12O3) was used in this study.
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Computed Properties of C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem