《Formal enantioselective total synthesis of bisdehydroneostemoninine》 was published in Journal of Asian Natural Products Research in 2020. These research results belong to Ma, Kai-Qing; Ren, Hu-Bin; Chao, Jian-Bin; Qin, Xue-Mei. Quality Control of 2,5-Dimethoxytetrahydrofuran The article mentions the following:
A formal enantioselective total synthesis of bisdehydroneostemoninine I employing L-glutamic acid as the chiral pool is described. The key features of the synthesis include regioselective and enantioselective opening of the chiral epoxide, (2R)-2-[3-[[(1,1-dimethylethyl)dimethylsilyl]oxy]propyl]oxirane with dimethylsulfonium methylide and tandem Friedel-Crafts cyclization followed by lactonization to form a 5-7-5 tricyclic core of the target stemona alkaloids I. The synthetic route provides opportunities to explore the biol. behavior of enantiopure compound I.2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Quality Control of 2,5-Dimethoxytetrahydrofuran) was used in this study.
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Quality Control of 2,5-Dimethoxytetrahydrofuran
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem