Bellin, Leo’s team published research in Nature Communications in 2021-12-31 | 58-97-9

Nature Communications published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Bellin, Leo; Del Cano-Ochoa, Francisco; Velazquez-Campoy, Adrian; Moehlmann, Torsten; Ramon-Maiques, Santiago published the artcile< Mechanisms of feedback inhibition and sequential firing of active sites in plant aspartate transcarbamoylase>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

Abstract: Aspartate transcarbamoylase (ATC), an essential enzyme for de novo pyrimidine biosynthesis, is uniquely regulated in plants by feedback inhibition of uridine 5-monophosphate (UMP). Despite its importance in plant growth, the structure of this UMP-controlled ATC and the regulatory mechanism remain unknown. Here, we report the crystal structures of Arabidopsis ATC trimer free and bound to UMP, complexed to a transition-state analog or bearing a mutation that turns the enzyme insensitive to UMP. We found that UMP binds and blocks the ATC active site, directly competing with the binding of the substrates. We also prove that UMP recognition relies on a loop exclusively conserved in plants that is also responsible for the sequential firing of the active sites. In this work, we describe unique regulatory and catalytic properties of plant ATCs that could be exploited to modulate de novo pyrimidine synthesis and plant growth.

Nature Communications published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Pengfei’s team published research in Separation and Purification Technology in 2022-01-01 | 4415-87-6

Separation and Purification Technology published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Li, Pengfei; Lan, Hongling; Chen, Kuo; Ma, Xiupeng; Wei, Bingxin; Wang, Ming; Li, Peng; Hou, Yingfei; Jason Niu, Q. published the artcile< Novel high-flux positively charged aliphatic polyamide nanofiltration membrane for selective removal of heavy metals>, Quality Control of 4415-87-6, the main research area is aliphatic polyamide nanofiltration membrane heavy metal removal separation.

The toxic heavy metals produced by the discharge of industrial wastewater pose a serious threat to the ecol. environment and human health. Nanofiltration (NF) membrane separation technol. is widely used in fields such as water softening, heavy metal removal and dye separation due to its environmental friendliness and low cost. Herein, a novel pos. charged aliphatic polyamide NF membrane (PEI-BTC) has been developed by using 1,2,3,4-cyclobutane tetracarboxylic acid chloride (BTC) monomer bearing a stereoscopic structure which undergoes classic interfacial polymerization (IP) with polyethyleneimine (PEI) on the Polyether sulfone (PES) support membrane. The physicochem. properties revealed that the PEI-BTC membrane had a larger mean effective pore size (0.285 nm), a thinner separation layer (40 nm) and a stronger pos. charged membrane surface (IEP = 7.25) than the traditional PEI-TMC membrane. Compared with previously reported PEI-based and com. NF membranes, the optimized PEI-BTC membrane exhibits a higher MgCl2 (2000 ppm) rejection of 97.53% and pure water flux of 156.85 kg·m-2·h-1 at 1.0 MPa. Moreover, the prepared PEI-BTC NF membrane shows excellent toxic heavy metal (1000 ppm) removal efficiency in the order of Mn (98.78%) > Zn (98.32%) > Ni (97.74%) > Cu (95.67%) > Cd (90.49%). The results demonstrate that the prepared pos. charged aliphatic polyamide NF membrane (PEI-BTC) has a unique industrial production potential for water softening and heavy metal removal.

Separation and Purification Technology published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Quality Control of 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Pirmoradi, Maryam’s team published research in ACS Omega in 2020-04-14 | 97-99-4

ACS Omega published new progress about Crystallites. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Pirmoradi, Maryam; Janulaitis, Nida; Gulotty, Robert J.; Kastner, James R. published the artcile< Continuous Hydrogenation of Aqueous Furfural Using a Metal-Supported Activated Carbon Monolith>, Formula: C5H10O2, the main research area is continuous hydrogenation aqueous furfural palladium activated carbon.

Continuous hydrogenation of aqueous furfural (4.5%) was studied using a monolith form (ACM) of an activated carbon Pd catalyst (~1.2% Pd). A sequential reaction pathway was observed, with ACM achieving high selectivity and space time yields (STYs) for furfuryl alc. (~25%, 60-70 g/L-cat/h, 7-15 1/h liquid hourly space velocity, LHSV), 2-methylfuran (~25%, 45-50 g/L-cat/h, 7-15 1/h LHSV), and tetrahydrofurfuryl alc. (~20-60%, 10-50 g/L-cat/h, <7 1/h LHSV). ACM showed a low loss of activity and metal leaching over the course of the reactions and was not limited by H2 external mass transfer resistance. Acetic acid (1%) did not significantly affect furfural conversion and product yields using ACM, suggesting Pd/ACM's potential for conversion of crude furfural. Limited metal leaching combined with high metal dispersion and H2 mass transfer rates in the composite carbon catalyst (ACM) provides possible advantages over granular and powd. forms in continuous processing. ACS Omega published new progress about Crystallites. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Formula: C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Audemar, Maite’s team published research in Energies (Basel, Switzerland) in 2020 | 97-99-4

Energies (Basel, Switzerland) published new progress about Batch bioreactors. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Audemar, Maite; Wang, Yantao; Zhao, Deyang; Royer, Sebastien; Jerome, Francois; Len, Christophe; De Oliveira Vigier, Karine published the artcile< Synthesis of furfuryl alcohol from furfural: a comparison between batch and continuous flow reactors>, Related Products of 97-99-4, the main research area is cobalt silica catalyst furfural hydrogenation furfuryl alc; continuous flow batch reactor.

Furfural is a platform mol. obtained from hemicellulose. Among the products that can be produced from furfural, furfuryl alc. is one of the most extensively studied. It is synthesized at an industrial scale in the presence of CuCr catalyst, but this process suffers from an environmental neg. impact. Here, we demonstrate that a non-noble metal catalyst (Co/SiO2) was active (100% conversion of furfural) and selective (100% selectivity to furfuryl alc.) in the hydrogenation of furfural to furfuryl alc. at 150°C under 20 bar of hydrogen. This catalyst was recyclable up to 3 cycles, and then the activity decreased. Thus, a comparison between batch and continuous flow reactors shows that changing the reactor type helps to increase the stability of the catalyst and the space-time yield. This study shows that using a continuous flow reactor can be a solution to the catalyst suffering from a lack of stability in the batch process.

Energies (Basel, Switzerland) published new progress about Batch bioreactors. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Li, Lei’s team published research in Nature Genetics in 2021-07-31 | 58-97-9

Nature Genetics published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Li, Lei; Huang, Kai-Lieh; Gao, Yipeng; Cui, Ya; Wang, Gao; Elrod, Nathan D.; Li, Yumei; Chen, Yiling Elaine; Ji, Ping; Peng, Fanglue; Russell, William K.; Wagner, Eric J.; Li, Wei published the artcile< An atlas of alternative polyadenylation quantitative trait loci contributing to complex trait and disease heritability>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is human alternative polyadenylation QTL linkage mapping disease heritability.

Genome-wide association studies have identified thousands of noncoding variants associated with human traits and diseases. However, the functional interpretation of these variants is a major challenge. Here, we constructed a multi-tissue atlas of human 3’UTR alternative polyadenylation (APA) quant. trait loci (3’aQTLs), containing approx. 0.4 million common genetic variants associated with the APA of target genes, identified in 46 tissues isolated from 467 individuals (Genotype-Tissue Expression Project). Mechanistically, 3’aQTLs can alter poly(A) motifs, RNA secondary structure and RNA-binding protein-binding sites, leading to thousands of APA changes. Our CRISPR-based experiments indicate that such 3’aQTLs can alter APA regulation. Furthermore, we demonstrate that mapping 3’aQTLs can identify APA regulators, such as La-related protein 4. Finally, 3’aQTLs are colocalized with approx. 16.1% of trait-associated variants and are largely distinct from other QTLs, such as expression QTLs. Together, our findings show that 3’aQTLs contribute substantially to the mol. mechanisms underlying human complex traits and diseases.

Nature Genetics published new progress about 3′-Untranslated region Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Goryanova, Bogdana’s team published research in Journal of the American Chemical Society in 2019-08-28 | 58-97-9

Journal of the American Chemical Society published new progress about Enzyme functional sites, active. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Goryanova, Bogdana; Amyes, Tina L.; Richard, John P. published the artcile< Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5'-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization>, Product Details of C9H13N2O9P, the main research area is decarboxylation orotidine monophosphate decarboxylase transition state stabilization.

Kinetic parameters kex (s-1) and kex/Kd (M-1s-1) are reported for exchange for deuterium in D2O of the C-6 hydrogen of 5-fluororotidine 5′-monophosphate (FUMP) catalyzed by the Q215A, Y217F, and Q215A/Y217F variants of yeast orotidine 5′-monophosphate decarboxylase (ScOMPDC) at pD 8.1, and by the Q215A variant at pD 7.1-9.3. The pD rate profiles for wildtype ScOMPDC and the Q215A variant are identical, except for a 2.5 log unit downward displacement in the profile for the Q215A variant. The Q215A, Y217F and Q215A/Y217F substitutions cause 1.3-2.0 kcal/mol larger increases in the activation barrier for wildtype ScOMPDC-catalyzed deuterium exchange compared with decarboxylation, because of the stronger apparent side chain interaction with the transition state for the deuterium exchange reaction. The stabilization of the transition state for the OMPDC-catalyzed deuterium exchange reaction of FUMP is ca. 19 kcal/mol smaller than the transition state for decarboxylation of OMP, and ca. 8 kcal/mol smaller than for OMPDC-catalyzed deprotonation of FUMP to form the vinyl carbanion intermediate common to OMPDC-catalyzed reactions OMP/FOMP and UMP/FUMP. We propose that ScOMPDC shows similar stabilizing interactions with the common portions of decarboxylation and deprotonation transition states that lead to formation of this vinyl carbanion intermediate, and that there is a large ca. (19-8) = 11 kcal/mol stabilization of the former transition state from interactions with the nascent CO2 of product. The effects of Q215A and Y217F substitutions on kcat/Km for decarboxylation of OMP are expressed mainly as an increase in Km for the reactions catalyzed by the variant enzymes, while the effects on kex/Kd for deuterium exchange are expressed mainly as an increase in kex. This shows that the Q215 and Y217 side chains stabilize the Michaelis complex to OMP for the decarboxylation reaction, compared with the complex to FUMP for the deuterium exchange reaction. These results provide strong support for the conclusion that interactions which stabilize the transition state for ScOMPDC-catalyzed decarboxylation at a nonpolar enzyme active site dominate over interactions that destabilize the ground-state Michaelis complex.

Journal of the American Chemical Society published new progress about Enzyme functional sites, active. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kato, Shunsuke’s team published research in Polymers (Basel, Switzerland) in 2019 | 4415-87-6

Polymers (Basel, Switzerland) published new progress about Electric breakdown. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Kato, Shunsuke; Yusof, Fitri Adila Amat; Harimoto, Toyohiro; Takada, Kenji; Kaneko, Tatsuo; Kawai, Mika; Mitsumata, Tetsu published the artcile< Electric volume resistivity for biopolyimide using 4,4'-diamino-α-truxillic acid and 1,2,3,4-cyclobutanetetracarboxylic dianhydride>, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is biopolyimide film volume resistivity elec insulation property; biopolyimide; biopolymer; electric resistivity; polyimide.

Biopolyimides poly(ATA-CBDA), made from of 4,4′-diamino-α-truxillic acid di-Me ester (ATA) and 1,2,3,4-cyclobutanetetracarboxylic dianhydride (CBDA), is synthesized and measured its elec. volume resistivity at various exptl. conditions. The effects of film size, thickness, drying time, and the elec. field strength on elec. resistivity are investigated and compared with polyimide (Kapton). The elec. resistivity for all polyimide and biopolyimide are distributed in the range of 1015-1016 Ωcm, which shows that biopolyimide has high elec. insulation as well as polyimide. The elec. resistivity strongly depends on film thickness, which suggests that elec. resistivity is a function of elec. field strength. The critical elec. field for polyimide and biopolyimide films are determined to be 5.8 x 107 V/m and 3.2 x 107 V/m, resp. Humidity was found to strongly affect the elec. resistivity; ~1016 Ωcm at 34% RH and ~1013 Ωcm at 60% RH for both polyimide and biopolyimide films.

Polymers (Basel, Switzerland) published new progress about Electric breakdown. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Safety of Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Povedano, M’s team published research in Pain management in 2019-03-01 | 58-97-9

Pain management published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Povedano, M; Martínez, Y; Tejado, A; Arroyo, P; Tebe, C; Lorenzo, J L; Montero, J published the artcile< Observational pilot study of patients with carpal tunnel syndrome treated with Nucleo CMP Forte™.>, Synthetic Route of 58-97-9, the main research area is carpal tunnel syndrome; electromyography; nucleotides; pain.

AIM: Carpal tunnel syndrome (CTS) is a very common entrapment neuropathy characterized by pain and paresthesia in the territory of the median nerve. Although this syndrome has a considerable impact on the patient’s quality of life, its medical treatment is far from optimal. MATERIAL & METHODS: We performed an observational study to evaluate Nucleo CMP ForteTM in patients with electromyography-confirmed, mild-moderate CTS. Pain was assessed using a visual analog scale, electromyogram and the SF-36. RESULTS: Pain decreased significantly after 6 months. Quality of life improved significantly in the pain dimensions. No significant differences were observed in electromyographic findings. No adverse events were reported. CONCLUSIONS: Nucleotides could prove useful for the nonsurgical treatment of CTS. Further studies are necessary to confirm this.

Pain management published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Synthetic Route of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Kumar, Abhinav’s team published research in ACS Applied Energy Materials in 2020-10-26 | 97-99-4

ACS Applied Energy Materials published new progress about Activation energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Kumar, Abhinav; Srivastava, Rajendra published the artcile< Pd-Decorated Magnetic Spinels for Selective Catalytic Reduction of Furfural: Interplay of a Framework-Substituted Transition Metal and Solvent in Selective Reduction>, Related Products of 97-99-4, the main research area is selective reduction furfural palladium magnetic spinel.

The reduction of functional platform chems., such as furfural, to industrially important chems. and fuel requires precise modulation of surface reactivity of the catalyst to obtain the desired reactivity and selectivity. In this study, the selective reduction of furfural (FAL) to furfuryl alc. (FOL) and tetrahydrofurfuryl alc. (THFA) is achieved by the transition metal interplay in the framework structure of magnetic spinels Fe3O4 and by modulating the reaction medium. Herein, FAL is selectively and quant. reduced to FOL in water at very mild reaction conditions over Pd-decorated CuFe2O4, whereas FAL is selectively converted to THFA in hexane at mild reaction conditions over Pd-decorated NiFe2O4, using H2 as an economical reducing agent. The Pd loading, reaction temperature, H2 pressure, and reaction time are minimized to obtain the best selectivity toward THFA. Different modes of FAL adsorption occur on CuFe2O4 and NiFe2O4 surfaces. Dissociative adsorption of H2 occurs on Pd sites to form Pd-H species, followed by transfer hydrogenation from Pd-H to FAL adsorbed on spinels, leading to the formation of FOL or THFA. Efficient magnetic recyclability and the hot filtration test show that the catalyst exhibits no significant loss in the activity even after five recycles. Catalysts exhibit very high activity, selectivity, and low activation energy, which are very attractive for academic and industrial points of view.

ACS Applied Energy Materials published new progress about Activation energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Related Products of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Liu, Qiaoyun’s team published research in Green Chemistry in 2020 | 97-99-4

Green Chemistry published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Liu, Qiaoyun; Qiao, Botao; Liu, Fei; Zhang, Leilei; Su, Yang; Wang, Aiqin; Zhang, Tao published the artcile< Catalytic production of 1,4-pentanediol from furfural in a fixed-bed system under mild conditions>, Category: tetrahydrofurans, the main research area is catalytic pentanediol furfural fixed bed system.

Furfural is one of the most important biomass-derived chems. Its large-scale availability calls for the exploration of new transformation methods for further valorization. Here we report on the direct, one-step conversion of furfural into 1,4-pentanediols (1,4-PeDs) using a combination of Amberlyst-15 and Ru-FeOx/AC catalysts. It is interesting to find that the introduction of a suitable amount of FeOx results in a great improvement in the dispersion of Ru and a decrease in the Lewis acidity. Both XPS and H2-TPR show that there is electron transfer from Ru to Fe, and the electronic interaction facilitates the reduction of both Ru and Fe species. When used in combination with Amberlyst-15, the Ru-6.3FeOx/AC catalyst afforded the best performance with a 1,4-PeD yield of 86%; by contrast, Ru/AC free of FeOx only gave levulinic acid as the major product, demonstrating the key role of the acid/metal balance in the one-pot conversion of furfural to 1,4-PeD. Moreover, such a dual catalyst exhibited excellent durability within 175 h time-onstream.

Green Chemistry published new progress about Biomass. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Category: tetrahydrofurans.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem