Day: October 12, 2022

El-Khayat, Hesham; Kamal, Enas M.; Yakoot, Mostafa; Gawad, Manal A.; Kamal, Naglaa; El Shabrawi, Mortada; Sameh, Yehia; Haseeb, Alaa; Fouad, Yasser; Attia, Dina published the artcile< Effectiveness of 8-week sofosbuvir/ledipasvir in the adolescent chronic hepatitis C-infected patients>, HPLC of Formula: 58-97-9, the main research area is chronic hepatitis effectiveness genotype human.

The sustained virol. response (SVR) rate for the 12-wk sofosbuvir (SOF)/ledipasvir (LVD) treatment of adolescent genotype-4 patients is high. The aim of this study is to evaluate 8 vs. 12-wk treatment efficacy and safety in adolescent genotype-4 patients. In total, 157 chronic hepatitis C-infected adolescent patients (mean age 14±2 years, 62% males) were included in this study. All patients received a morning dose of SOF (400 mg)/LVD (90 mg) as a single tablet for 8 and 12 wk. Laboratory and biochem. monitoring were performed at weeks 4 and 8, end of treatment (8/12) and 12 wk after the end of treatment (SVR12). In total, SVR12 was 98% [95% confidence interval (CI): 96-100] for all treated patients. For patients treated for 12 wk, SVR12 was 97.6% (95% CI: 96-101) (82/84 patients), and 98.6% (95% CI: 93-101) (72/73) patients for those treated for 8 wk. For both regimens, no serious adverse effects, treatment discontinuation or cases of death were detected. The main adverse effects for the 8-wk patient group were fatigue (2.8%), headache (1.4%), nausea (1.4%) and epigastric tenderness (1.4%). For the 12-wk-treated group, adverse events were epigastric tenderness (1.2%), nausea (1.2%), diarrhoea (2.4%) and rash (2.4%). Three patients were lost to follow-up: two were in the 12-wk treatment group and one was in the 8-wk group. All of them reached end of treatment but were lost before SVR12. No relapsers were observed in either group. Eight weeks of treatment of SOF/LVD combination is equally effective and safe as 12 wk in adolescent genotype-4 patients.

European Journal of Gastroenterology & Hepatology published new progress about Chronic hepatitis. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Qiao, Du; Cheng, Luo; Xiaomei, Tian; Baolei, Shi; Yingyi, Li; Hui, Zhang; Shaohua, Bian; Wei, Liu; U, Dai Y; Fangqiong, Deng; Jie, Liu; Shuangning, Liu published the artcile< Effect of ultra-mini percutaneous nephrolithotomy and ShuoTong ureteroscopy on the stress response, inflammatory indices, and urokinase level in patients with polycystic kidney disease complicated with renal calculus.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

This study aimed to explore the effects of ultra-mini percutaneous nephrolithotomy (UMP) combined with ShuoTong ureteroscopy on the stress response, inflammation indicators and urokinase levels in patients with polycystic kidney disease and kidney stones. In this study, 42 patients with polycystic kidney disease and kidney stones diagnosed and treated in our hospital from February 2018 to February 2021 were selected as the research objects. They were randomly divided into the control group and the study group, with 21 cases in each group, and the control group adopted Ultra-mini percutaneous nephrolithotomy treatment; the study group was combined with ShuoTong ureteroscopy on the basis of the control group, and compared and analyzed the stress response, inflammation indexes, urokinase level, renal function, complications and stone clearance rate of the two groups of patients. After treatment, the average operation time, channel establishment time, hemoglobin decline, number of puncture channels, and hospital stay in the study group were significantly shorter than those in the control group (P<0.05); after treatment, the reduction in CRP and PCT in the study group was significantly higher than that in the control group The increase of Ang I and Ang II in the control group was significantly lower than that in the control group (P<0.05); the improvement of PGE2, NO, and LPO levels in the study group was significantly higher than that in the control group after treatment (P<0.05); the study group TH, Cys- The levels of C and β2-MG were significantly lower than those of the control group; the UK levels of the study group were significantly lower than those of the control group (P<0.05); the complication rate of 14.29% in the study group after treatment was significantly lower than that of the control group 33.33%; the study group The stone clearance rate of 95.24% was significantly higher than that of the control group 80.95% (P<0.05). In general, UMP combined with ShuoTong ureteroscopy is used to treat polycystic kidney with kidney stones, accurately determine the tip position of the needle sheath, ensure that the needle sheath enters the collection system to adjust its position, reduce patient stress and inflammation, improve safety and feasibility, and is worthy of clinical practice Promote applications. Cellular and molecular biology (Noisy-le-Grand, France) published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Tian, Hongli; Gao, Guoming; Xu, Qing; Gao, Zhiran; Zhang, Shu; Hu, Guangzhi; Xu, Leilei; Hu, Xun published the artcile< Facilitating selective conversion of furfural to cyclopentanone via reducing availability of metallic nickel sites>, SDS of cas: 97-99-4, the main research area is furfural cyclopentanone hydrogenation nickel catalyst.

Conversion of the biomass-derived furfural to cyclopentanone (CPO) involves multiple hydrogenation steps, in which not only the type but also the abundance of metallic sites might impact fates of the reaction intermediates and consequently selectivity of the products. In this study, we found that, during the hydrogenation, the carbonyl and the furan ring functionalities in furfural showed the different response to the number of nickel sites on Ni/SiO2 catalyst. The hydrogenation of the C = O in furfural could take place effectively with the nickel loading below 1 wt% to form firstly furfuryl alc. (FA) and then to CPO with the selectivity as high as 98.2%. In comparison, the higher nickel loading favored the hydrogenation of the furan ring in furfural or FA to form tetrahydrofurfuryl alc. (THFA), formation of which eliminated the chance for the formation of CPO. The hydrogenation of the carbonyl functionality and furan ring in furfural proceeded via distinct orientations of adsorption and the involvement of the varied number of metal sites. Controlling the number of exposed metallic nickel sites could thus tailor the selectivity of the products in hydrogenation of furfural.

Molecular Catalysis published new progress about Agglomeration. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, SDS of cas: 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Papadopoulos, Giorgos N.; Kokotou, Maroula G.; Spiliopoulou, Nikoleta; Nikitas, Nikolaos F.; Voutyritsa, Errika; Tzaras, Dimitrios I.; Kaplaneris, Nikolaos; Kokotos, Christoforos G. published the artcile< Phenylglyoxylic Acid: An Efficient Initiator for the Photochemical Hydrogen Atom Transfer C-H Functionalization of Heterocycles>, Reference of 97-99-4, the main research area is heterocycle green preparation phenylglyoxylic acid catalyst hydrogen atom transfer; C−H activation; hydrogen atom transfer; metal-free processes; phenylglyoxylic acid; photochemistry.

A cheap and efficient photochem. method was developed for the C-H functionalization of heterocycles was studied. Phenylglyoxylic acid (PhCOCOOH) would behave as an alternative to metal-based catalysts and organic dyes and provided a very general and wide array of photochem. C-H alkylation, alkenylation, and alkynylation, as well as C-N bond forming reaction methodologies. This novel, mild, and metal-free protocol was successfully employed in the functionalization of a wide range of C-H bonds, utilized not only O- or N-heterocycles, but also the less studied S-heterocycles.

ChemSusChem published new progress about C-H bond activation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lin, Chia-Ching; Shen, Yi-Ru; Chang, Chi-Chih; Guo, Xiang-Yi; Young, Yun-Yun; Lai, Ting-Yu; Yu, I-Shing; Lee, Chih-Yuan; Chuang, Tsung-Hsien; Tsai, Hsin-Yue; Hsu, Li-Chung published the artcile< Terminal uridyltransferase 7 regulates TLR4-triggered inflammation by controlling Regnase-1 mRNA uridylation and degradation>, Product Details of C9H13N2O9P, the main research area is terminal uridyltransferase 7 TLR4 regenase1 uridylation inflammation.

Different levels of regulatory mechanisms, including posttranscriptional regulation, are needed to elaborately regulate inflammatory responses to prevent harmful effects. Terminal uridyltransferase 7 (TUT7) controls RNA stability by adding uridines to its 3 ends, but its function in innate immune response remains obscure. Here we reveal that TLR4 activation induces TUT7, which in turn selectively regulates the production of a subset of cytokines, including Interleukin 6 (IL-6). TUT7 regulates IL-6 expression by controlling RNase Regnase-1 mRNA (encoded by Zc3h12a gene) stability. Mechanistically, TLR4 activation causes TUT7 to bind directly to the stem-loop structure on Zc3h12a 3-UTR, thereby promotes Zc3h12a uridylation and degradation Zc3h12a from LPS-treated TUT7-sufficient macrophages possesses increased oligo-uridylated ends with shorter poly(A) tails, whereas oligo-uridylated Zc3h12a is significantly reduced in Tut7-/- cells after TLR4 activation. Together, our findings reveal the functional role of TUT7 in sculpting TLR4-driven responses by modulating mRNA stability of a selected set of inflammatory mediators.

Nature Communications published new progress about Animal gene Role: BSU (Biological Study, Unclassified), PRP (Properties), BIOL (Biological Study) (Tut4). 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Coffin, Phillip O.; Santos, Glenn-Milo; Behar, Emily; Hern, Jaclyn; Walker, John; Matheson, Tim; Kinnard, Elizabeth N.; Silvis, Janelle; Vittinghoff, Eric; Fox, Rena; Page, Kimberley published the artcile< Randomized feasibility trial of directly observed versus unobserved hepatitis C treatment with ledipasvir-sofosbuvir among people who inject drugs>, Electric Literature of 58-97-9, the main research area is hepatitis C infection ledipasvir sofosbuvir feasibility acceptability.

We conducted a 2:1 randomized trial of modified directly-observed (mDOT) vs. unobserved HCV treatment with ledipasvir-sofosbuvir daily for 8 wk among PWID with 36 wk of follow-up in San Francisco from 2015-2017. We evaluated recruitment-enrollment, treatment completion, end-of-treatment and 12-wk response, and reinfection rate. Results: Of 83 individuals eligible for screening, 72 (87.6%) attended the screening visit, 33 were eligible, and 31 enrolled; mean age was 42 years, 81% were male, 74% white. All but one participant (in the mDOT arm) completed treatment and 89.4% of mDOT and 96.6% of unobserved arm visits were attended. HCV was undetectable for 96.8% (30/31) at end of treatment and 89.7% (26/29) 12 wk later (1 relapse, 1 reinfection), with no differences by arm. Two addnl. reinfections were subsequently identified, for a reinfection rate of 16.3 (95% CI 5.3-50.5) per 100 person-years of observation. Conclusions: It was feasible to recruit active PWID for HCV treatment and achieve high retention, viral response, and satisfaction with either mDOT or unobserved protocols, supporting treatment of PWID at risk of transmitting HCV to others. The reinfection rate suggests we successfully reached a high-risk population and that successful HCV TasP initiatives may aim to be sufficient in scope to significantly lower prevalence in the community. Trial registration: clinicaltrials.gov NCT02609893.

PLoS One published new progress about Drug safety. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Electric Literature of 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Parlati, Lucia; Sirmai, Laura; Dupuy, Claire-Antoinette; Glotz, Denis; Pol, Stanislas published the artcile< Evidence of HCV recovery after therapy of hepatitis C virus infection by direct acting antivirals.>, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is .

There is no abstract available for this document.

Clinics and research in hepatology and gastroenterology published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Recommanded Product: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Lenz, Destin U; Crutcher, Effie L; Greene, Elisa M published the artcile< Sexual Dysfunction in a Patient Taking Ledipasvir/Sofosbuvir for the Treatment of Hepatitis C: A Case Report.>, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate, the main research area is Harvoni®; hepatitis C virus; ledipasvir/sofosbuvir; sexual dysfunction.

Sexual dysfunction is a bothersome side effect of several medications, though it has not yet been reported with the use of ledipasvir/sofosbuvir for the treatment of hepatitis C. However, sexual dysfunction is a potentially unrecognized side effect of ledipasvir/sofosbuvir that could result in nonadherence and treatment failure. We report a case of a 42-year-old man with a sudden onset of sexual dysfunction with the initiation of ledipasvir/sofosbuvir for the treatment of hepatitis C. The patient had no prior history or risk factors for the development of sexual dysfunction. His symptoms resolved upon discontinuation of ledipasvir/sofosbuvir after a successful 12-week course. Clinicians should be aware that sexual dysfunction is a possible side effect of ledipasvir/sofosbuvir and educate patients appropriately. Adherence should be emphasized as the risks of untreated hepatitis C virus far outweigh transient sexual dysfunction.

Journal of pharmacy practice published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Name: ((2R,3S,4R,5R)-5-(2,4-Dioxo-3,4-dihydropyrimidin-1(2H)-yl)-3,4-dihydroxytetrahydrofuran-2-yl)methyl dihydrogen phosphate.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Burke, Patrick M.; Reynolds, William F.; Tam, Janet C. L.; Yates, Peter published the artcile< The assignment of proton and carbon-13 chemical shifts for dihydro-3(2H)-furanone derivatives by means of specific deuterium labeling experiments and 13C{1H} decoupling experiments>, Product Details of C8H14O2, the main research area is PMR hydrotetramethylfuranone; furanone dihydrotetramethyl carbon NMR; ring cleavage methyldihydrofuranone acid.

The PMR of I(R=Me,R2=H)(II) in 80% H2SO4 shows a time-dependent decrease in the intensity of the lower-field gem-di-Me signal relative to the upper-field gem-di-Me signal. Due to the reversible opening of II to 2-hydroxy-2,5-dimethyl-4-hexen-3-one which results in D exchange at the C-5 Me groups of II. The lower-field gem-di-Me signal of II in this medium is therefore assigned to these Me groups. A similar relation between the Me proton signals of II in organic solvents is demonstrated by synthesis of I(R=CD3, R1=D), comparison of the PMR and its 2,2- and 5,5-di-Me analogs. and observation of long range coupling in the spectrum of II. Assignment of 13C chem. shifts for II are made based on proton-coupled spectra, showing that the signal of the C-5 Me carbons appears at ∼4 ppm towards lower field than that of the C-2 Me carbons. Both the 1H and 13C chem. shift assignments for II are confirmed from 13C{1H} spectra using low power single frequency 1H decoupling.

Canadian Journal of Chemistry published new progress about Exchange reaction. 5455-94-7 belongs to class tetrahydrofurans, and the molecular formula is C8H14O2, Product Details of C8H14O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Mironenko, Roman M.; Belskaya, Olga B.; Talsi, Valentin P.; Likholobov, Vladimir A. published the artcile< Mechanism of Pd/C-catalyzed hydrogenation of furfural under hydrothermal conditions>, Reference of 97-99-4, the main research area is palladium carbon nanotube catalyst hydrothermal condition furfural hydrogenation mechanism.

Catalytic hydrogenation of furfural under hydrothermal conditions is of great importance and has recently attracted huge attention as an approach to obtaining a wide range of valuable chems. from a renewable source. However, the data concerning the reaction mechanism of aqueous-phase furfural hydrogenation are very scarce, and it is still not clear which reactions lead to various carbonyl compounds, such as cyclopentanone, 4-oxopentanal, 5-hydroxy-2-pentanone. Herein, we present the results of an exptl. study of the mechanism of reactions occurring in the furfural hydrogenation under hydrothermal conditions over the 1% Pd/CNTs catalyst. The following approaches have been used to study the reaction mechanism: hydrogenation of key intermediates formed upon the furfural conversion, and isotopic labeling experiments using D2O as a tracer in hydrogenation of furfural, which provides direct evidence of the occurring reactions. It was found that the furfural hydrogenation process is realized through four pathways including various reductive and acid-catalyzed furan ring opening reactions. The methods and approaches used in the present work, as well as the results obtained, can be useful in studying the mechanism of aqueous-phase hydrogenation of a wide range of oxygen-containing substrates in the presence of catalysts of different compositions

Journal of Catalysis published new progress about Carbon nanotubes (catalyst support). 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Reference of 97-99-4.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem