Xie, Chun-yan; Wang, Qinhua; Li, Guanya; Fan, Zhiyong; Wang, Hong; Wu, Xin published the artcile< Dietary supplement with nucleotides in the form of uridine monophosphate or uridine stimulate intestinal development and promote nucleotide transport in weaned piglets>, Electric Literature of 58-97-9, the main research area is piglet UMP uridine dietary supplement intestine development nucleotide transport; intestinal development; uridine; uridine monophosphate; weaned piglets.
BACKGROUND : Nucleotides are key constituents of milk, where they are utilized in cell replication, although there are limited studies for weaned piglets. This study evaluated the effects of uridine monophosphate (UMP) with uridine (UR) feed supplementation on the intestinal development and nucleotide transport in weaned piglets. RESULTS : Supplementation with UMP significantly increased (P ≤ 0.05) plasma glucose, and UR supplementation significantly reduced (0.05 ≤ P ≤ 0.10) the plasma total cholesterol (TC) of piglets when compared with that of the control group, although non-significant difference (P ≥ 0.05) in growth performance was observed among three groups. Piglets fed supplementary UR exhibited greater (P ≤ 0.05) crypt depth in the duodenum and ileum when compared with those in the supplementary UMP and control groups. Real-time quant. polymerase chain reaction (RT-qPCR) results revealed that UR supplementation increased (P ≤ 0.05) the relative mRNA levels of genes encoding the transmembrane proteins ZO-1 and occludin in the duodenum mucosa, and ZO-1 in the jejunum mucosa (P ≤ 0.05). Similarly, UR supplementation increased (P ≤ 0.05) expression of solute carriers SLC28A1 and SLC29A1 in the duodenum mucosa. Conversely, claudin-1 expression in the duodenum mucosa was inhibited (P ≤ 0.05) by dietary supplementation with UMP or UR. CONCLUSION : Collectively, our data indicated that dietary supplementation with UMP or UR was conducive to stimulating intestinal development and promoting nucleotide transport in weaned piglets.
Journal of the Science of Food and Agriculture published new progress about Body weight. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Electric Literature of 58-97-9.
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem