Formula: C6H12O3In 2022 ,《Facile and Scalable Methodology for the Pyrrolo[2,1-f][1,2,4]triazine of Remdesivir》 appeared in Organic Process Research & Development. The author of the article were Roy, Sarabindu; Yadaw, Ajay; Roy, Subho; Sirasani, Gopal; Gangu, Aravind; Brown, Jack D.; Armstrong, Joseph D. III; Stringham, Rodger W.; Gupton, B. Frank; Senanayake, Chris H.; Snead, David R.. The article conveys some information:
Pyrrolo[2,1-f][1,2,4]triazine (I) is an important regulatory starting material in the production of the antiviral drug remdesivir. Compound I was produced through a newly developed synthetic methodol. utilizing simple building blocks such as pyrrole, chloramine, and formamidine acetate by examining the mechanistic pathway for the process optimization exercise. Triazine I was obtained in 55% overall yield in a two-vessel-operated process. This work describes the safety of the process, impurity profiles and control, and efforts toward the scale-up of triazine for the preparation of kilogram quantity. In the experimental materials used by the author, we found 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Formula: C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem