Formula: C6H12O3In 2022 ,《A solvent-free manganese(II) -catalyzed Clauson-Kaas protocol for the synthesis of N-aryl pyrroles under microwave irradiation》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Rohit, Kizhakkekuttu Radhakrishnan; Meera, Gopinadh; Anilkumar, Gopinathan. The article conveys some information:
The first manganese-catalyzed modified Clauson-Kaas reaction for N-substituted pyrroles I (R = Ph, 2-bromo-4-methylphenyl, 1,3-benzothiazol-2-yl, etc.) synthesis using 2,5-dimethoxytetrahydrofuran with variously substituted aromatic amines RNH2 has been developed (up to 89% yield). This interesting neat strategy is free from additives including co-catalysts, ligands, and acids. Relatively low cost, environmentally benign, and handy Mn(NO3)2.4H2O is employed as the catalyst under microwave conditions with a very short reaction time (20 min). The above qualities attest to the green nature of this reaction. In the part of experimental materials, we found many familiar compounds, such as 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)
2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Formula: C6H12O3
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem