Day: October 11, 2022

Formula: C6H12O3In 2020 ,《Synthesis and characterization of some new S-substituted sulfanylpyridines, thieno[2,3-b]pyridines and related heterocycles》 was published in ARKIVOC (Gainesville, FL, United States). The article was written by Al-Taifi, Elham A.; Al-Waleedy, Safiyyah A. H.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.; Marae, Islam S.; Abuelhassan, Suzan; Bakhite, Etify A.. The article contains the following contents:

Et (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2-pyridylsulfanyl)acetate was prepared and reacted with hydrazine hydrate in ethanol to give a mixture of (3-cyano-5-ethoxycarbonyl-6-methyl-4-styryl-2- pyridylsulfanyl)acetohydrazide and di-Et 3-amino-6-methyl-4-styrylthieno[2,3-b]pyridine-2,5-dicarboxylate. The latter compound was reacted with 2,5-dimethoxytetrahydrofuran to give 3-(1H-pyrrol-1-yl)thieno[2,3-b]pyridine analog which on treatment with hydrazine hydrate in ethanol furnished 5-ethoxycarbonyl-6- methyl-3-(1H-pyrrol-1-yl)-4-styrylthieno[2,3-b]pyridine-2-carbohydrazide. Both acetohydrazide and carbohydrazide were used as precursors for the title compounds The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Formula: C6H12O3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Formula: C6H12O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Thin layer chromatography and GC-MS analysis of bioactive molecules of the Acacia ferruginea DC. thorn extract》 was published in Asian Journal of Biological and Life Sciences in 2021. These research results belong to Malathi, H.; Thamizhseran, N.. Synthetic Route of C4H6O3 The article mentions the following:

The aim of the current study is to investigate thethin layer chromatog. (TLC) and gas chromatog. and mass spectroscopy anal. (GC-MS) of methanolic extract of Acacia ferruginea thorns. The bioactive mols. were determined by qual. TLC and GC-MS method. In TLC exhibited maximum 0.6 retention factor (RF) value of the plant extract in F254 wavelength in dark blue color, F366 wave length and in visible light not shown any peaks and RF values. In the GC-MS anal., 37 bioactive mols. were exhibited and in that 10 are in higher concentration by the retention time and their % of peak and area covered in the anal. compared to other chromatograms of the fractions. Important compounds identified as Me mannose (57.14), Phenol, 2-methoxy-3-(2-propenyl)- (4.85), stigmasterol (4.65), 1-Hexacosanol (3.83), Lupeol (3.60), gamma Sitosterol (3.52), Phenol, 4-[2-(dimethylamino)ethyl]-(3.17), Ergost-5-en- 3-ol, (3.beta.)- (2.53), Oleic acid (2.44), Oleoyl chloride (1.53), Sucrose (1.82). The presence of these bioactive mols. in the plant extract may provide the scientific evidences for the cytotoxic effect, insecticidal and other biol. properties. The experimental process involved the reaction of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Synthetic Route of C4H6O3)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Synthetic Route of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Quality Control of 3-Hydroxydihydrofuran-2(3H)-oneOn September 1, 2021 ,《Depsipeptide nucleic acids: Prebiotic formation, oligomerization, and self-assembly of a new proto-nucleic acid candidate》 was published in Journal of the American Chemical Society. The article was written by Fialho, David M.; Karunakaran, Suneesh C.; Greeson, Katherine W.; Martinez, Isaac; Schuster, Gary B.; Krishnamurthy, Ramanarayanan; Hud, Nicholas V.. The article contains the following contents:

The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process remains challenging. Alternatively, RNA may have been preceded by an earlier ancestral polymer, or proto-RNA, that had a greater propensity for self-assembly than RNA, with the eventual transition to functionally superior RNA being the result of chem. or biol. evolution. We report a new class of nucleic acid analog, depsipeptide nucleic acid (DepsiPNA), which displays several properties that are attractive as a candidate for proto-RNA. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these DepsiPNA oligomers are capable of complementary self-assembly and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers on the early earth may have been relatively facile if the constraints of an RNA-first scenario are relaxed. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The author of 《Identification of novel 3-hydroxy-pyran-4-one derivatives as potent HIV-1 integrase inhibitors using in silico structure-based combinatorial library design approach》 were Sirous, Hajar; Chemi, Giulia; Gemma, Sandra; Butini, Stefania; Debyser, Zeger; Christ, Frauke; Saghaie, Lotfollah; Brogi, Simone; Fassihi, Afshin; Campiani, Giuseppe; Brindisi, Margherita. And the article was published in Frontiers in Chemistry (Lausanne, Switzerland) in 2019. Category: tetrahydrofurans The author mentioned the following in the article:

The development and exptl. validation of a computational protocol for optimizing a series of 3-hydroxy-pyran-4-one derivatives I [R = 2-(3-fluorophenyl)pyridinyl, 2-methyl-4-phenyl-1-imidazolyl, 1-phenyl-1H-pyrrolyl] as HIV integrase inhibitors (HIV INIs) was repoted. Starting from a previously developed micromolar inhibitors of HIV integrase (HIV IN), in-depth investigation based on an in silico structure-based combinatorial library designing approach was reported. This method combined a combinatorial library design and side chain hopping with Quantum Polarized Ligand Docking (QPLD) studies and mol. dynamics simulation. The resulting compounds I were assessed by the mentioned QPLD methodol. using a homol. model of full-length binary HIV IN/DNA for retrieving the best performing compounds acted as HIV INIs. Along with the prediction of physico-chem. properties, limited number of drug-like compounds were potentially displayed potent HIV IN inhibition. The compounds I were exptl. assessed in vitro for evaluating overall HIV-1 IN inhibition, HIV-1 IN strand transfer activity inhibition, HIV-1 activity inhibition and cellular toxicity. Gratifyingly, all of them showed relevant inhibitory activity in the in vitro tests along with no toxicity. Among them compound I [R = 2-(3-fluorophenyl)pyridinyl] represented the most promising compound as potential anti-HIV agent, showed inhibitory activity against HIV IN in the low nanomolar range comparable to that found for Raltegravir and relevant potency in inhibiting HIV-1 replication and HIV-1 IN strand transfer activity. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Category: tetrahydrofurans)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Category: tetrahydrofurans

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Alqahtani, Yahya S.; Kumar, S. R. Prem; Pavitra, H.; Joshi, Shrinivas D. published an article in 2021. The article was titled 《Synthesis, computational docking, and antimycobacterial study of novel N’-phenyl-4-pyrrol-1-yl-benzenesulfonamide derivatives》, and you may find the article in Indian Journal of Heterocyclic Chemistry.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran The information in the text is summarized as follows:

Fresh sequences of pyrrole linked N’-phenyl-4-pyrrolyl-benzenesulfonamide derivatives were synthesized by different synthetic methods. Synthesis of the N’-phenyl-4-(1H-pyrrol-1-yl) benzenesulfonamides/4-(2,5-dimethyl-1H-pyrrol-1-yl)-N’-phenylbenzenesulfonamides was achieved by refluxing 2,5-dimethoxytetrahydrofuran/hexane 2,5-dione sep. in presence of acetic acid. Further, synthesis of N-(4-(N’-phenylsulfamoyl)phenyl)-4-(1H-pyrrol-1-yl)benzamides/4-(2,5-dimethyl-1H-pyrrol-1-yl)-N-(4-(N’-phenylsulfamoyl)phenyl)benzamides was achieved by cold stirring of 4-(1H-pyrrol-1-yl)benzoic acid/4-(2,5-dimethyl-1H-pyrrol-1-yl)benzoic acid correspondingly in the presence of 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, N’,N’-diisopropylethylamine, and DMF. In vitro anti-tubercular study of afresh compounds has shown good min. inhibitory concentration values (0.4-12.5μg/mL) counter to Mycobacterium tuberculosis H37Rv, while the corresponding study of reported mols. for antibacterial activity disclosed considerable inhibition values (0.4-25μg/mL) counter to Escherichia coli (Gram – ve) than Staphylococcus aureus (Gram + ve). In addition to this study using 2,5-Dimethoxytetrahydrofuran, there are many other studies that have used 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Application In Synthesis of 2,5-Dimethoxytetrahydrofuran) was used in this study.

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Application In Synthesis of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 696-59-3In 2020 ,《Synthesis and characterization of some new pyridines, thieno[2,3-b] pyridines and pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones bearing styryl moiety》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Al-Waleedy, Safiyyah A. H.; Bakhite, Etify A.; Abbady, Mohamed S.; Abdu-Allah, Hajjaj H. M.. The article conveys some information:

Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. Reaction of compound 3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridine-2(1H)-thione with some N-aryl-2-chloroacetamides, in the presence of sodium acetate, gave the corresponding 2-(N-arylcarbamoylmethylsulfanyl)-3-cyano-5-ethoxycarbonyl-6-methyl-4-styrylpyridines I [R1 = H, Me, NO2, etc.]. When compounds I were subjected to Thorpe-Ziegler reaction conditions, they converted into the corresponding 3-amino-5-ethoxycarbonyl-2-(N-arylcarbamoyl)-6-methyl-4-styrylthieno[2,3-b]pyridines II [R2 = NH2]. Compounds II [R1 = H, Cl, NO2, R2 = NH2] were reacted, in turn, with 2,5-dimethoxytetrahydrofuran to furnish the corresponding 3-(pyrrol-1-yl)thieno-pyridines II [R2 = 1-pyrrolyl]. Reactions of II [R2 = NH2] with tri-Et orthoformate were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d]pyrimidine-4(3H)-ones III [X = C]. Reactions of compounds II [R1 = OMe, Cl, R2 = NH2] with nitrous acid were also carried out to form 3-aryl-8-acetyl-7-methyl-9-styrylpyrido[3′,2′:4,5]thieno[3,2-d][1,2,3]triazine-4(3H)-ones III [X = N]. Structural formulas of all synthesized compounds I, II and III were characterized and confirmed on the basis of their elemental and spectral analyzes. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Product Details of 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. When aromatic ethers are exposed to halogen in the presence or absence of a catalyst, they undergo halogenation, such as bromination.Product Details of 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Safety of 2,5-DimethoxytetrahydrofuranIn 2022 ,《Lactam Strategy Using Amide-Selective Nucleophilic Addition for Quick Access to Complex Amines: Unified Total Synthesis of Stemoamide-Type Alkaloids》 was published in Bulletin of the Chemical Society of Japan. The article was written by Sugiyama, Yasukazu; Soda, Yasuki; Yoritate, Makoto; Tajima, Hayato; Takahashi, Yoshito; Shibuya, Kana; Ogihara, Chisato; Yokoyama, Takashi; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka. The article contains the following contents:

In this article, the authors report full details of the unified total synthesis of stemoamide-type alkaloids by chemoselective assembly of five-membered rings based on the lactam strategy. First, the concise and gram-scale synthesis of tricyclic stemoamide was achieved by vinylogous Michael addition-reduction sequence of an unsaturated γ-lactam with an unsaturated γ-lactone, followed by N-alkylation to form the seven-membered ring. From stemoamide as a common intermediate, chemoselective nucleophilic addition of unsaturated lactone derivatives provided tetracyclic natural products. While stemonine was obtained by an Ir-catalyzed lactam-selective reductive Mannich reaction, saxorumamide and isosaxorumamide were produced through the lactone-selective nucleophilic addition of the lithiated 2-silyl furan. The developed conditions for the lactam-selective nucleophilic reactions were highly general, and were found to be applicable to the total synthesis of pentacyclic stemocochinin and isostemocochinin. The strategy enabled the concise and unified total synthesis of tricyclic, tetracyclic and pentacyclic stemoamide-type alkaloids within 12 steps from a com. available compound The experimental part of the paper was very detailed, including the reaction process of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Safety of 2,5-Dimethoxytetrahydrofuran)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Safety of 2,5-Dimethoxytetrahydrofuran

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《Fast Pyrolysis Oil Upgrading via HDO with Fe-Promoted Nb2O5-Supported Pd-Based Catalysts》 was published in Energies (Basel, Switzerland) in 2022. These research results belong to Campos Fraga, Mariana Myriam; Lacerda de Oliveira Campos, Bruno; Hendrawidjaja, Handoyo; Carriel Schmitt, Caroline; Raffelt, Klaus; Dahmen, Nicolaus. Synthetic Route of C4H6O3 The article mentions the following:

Due to the high acid, oxygen and water contents of fast pyrolysis oil, it requires the improvement of its fuel properties by further upgrading, such as catalytic hydrodeoxygenation (HDO). In this study, Nb2O5 was evaluated as a support of Pd-based catalysts for HDO of fast pyrolysis oil. A Pd/SiO2 catalyst was used as a reference Addnl., the impact of iron as a promoter in two different loadings was investigated. The activity of the synthesized catalysts was evaluated in terms of H2 uptake and composition of the upgraded products (gas phase, upgraded oil and aqueous phase) through elemental anal., Karl Fischer titration, GC-MS/FID and 1H-NMR. In comparison to SiO2, due to its acid sites, Nb2O5 enhanced the catalyst activity toward hydrogenolysis and hydrogenation, confirmed by the increased water formation during HDO and a higher content of hydrogen and aliphatic protons in the upgraded oil. Consequently, the upgraded oil with Nb2O5 had a lower average mol. weight and was therefore less viscous than the oil obtained with SiO2. When applied as a promoter, Fe enhanced hydrogenation and hydrogenolysis, although it slightly decreased the acidity of the support, owing to its oxophilic nature, leading to the highest deoxygenation degree (42.5 weight%) and the highest product HHV (28.2 MJ/kg). In addition to this study using 3-Hydroxydihydrofuran-2(3H)-one, there are many other studies that have used 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Synthetic Route of C4H6O3) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Synthetic Route of C4H6O3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

《IRMOF-3 biological activity enhancement by post-synthetic modification》 was written by Abdelhameed, Reda M.; Darwesh, Osama M.; Rocha, Joao; Silva, Artur M. S.. Recommanded Product: 696-59-3This research focused onzinc metal organic framework IRMOF3 derivative nanoparticle antimicrobial. The article conveys some information:

The growing resistance of pathogens to conventional antibiotics has become a public health problem requiring novel effective solutions In this context, metal-organic frameworks (MOFs) are attracting attention because they can act as reservoirs releasing metal ions with antibacterial properties. This action is reminiscent of that proposed for metal- and metal oxide-nanoparticles but different from the action of antibiotics. These features make MOFs promising candidates for pharmaceutical and biomedical applications. Here, IRMOF-3 was modified with 2,5-dimethoxytetrahydrofuran, N,N’-disuccinimidyl carbonate, acryloyl chloride, and phthalaldehyde to produce, resp., IRMOF-3-FU, IRMOF-3-SU, IRMOF-3-AC, IRMOF-3-DL in 38 to 90% yields. Remarkably, the biol. activity of these compounds evaluated against various bacterial and fungal strains is higher than the activity of com. antibiotics. The results came from multiple reactions, including the reaction of 2,5-Dimethoxytetrahydrofuran(cas: 696-59-3Recommanded Product: 696-59-3)

2,5-Dimethoxytetrahydrofuran(cas: 696-59-3) is a member of ether. Friedel Crafts reaction, for example, adds an alkyl or acyl group to aromatic ethers when they react with an alkyl or acyl halide in the presence of a Lewis acid as a catalyst.Recommanded Product: 696-59-3

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In 2021,World News of Natural Sciences included an article by James-Okoro, Paula-Peace O.; Iheagwam, Franklyn N.; Sholeye, Mariam I.; Umoren, Itoroobong A.; Adetuyi, Babatunde O.; Ogundipe, Adebanke E.; Braimah, Adefoyeke A.; Adekunbi, Tobi S.; Ogunlana, Oluseyi E.; Ogunlana, Olubanke O.. Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one. The article was titled 《Phytochemical and in vitro antioxidant assessment of Yoyo bitters》. The information in the text is summarized as follows:

In this paper, herbal bitters are widely used due to their numerous acclaimed health benefits in many Nigerian homes; however, many have not been subjected to scientific scrutiny. The aim of this study was to determine the phytochem. composition and antioxidant capacity of a non-alc. polyherbal formulation, Yoyo bitters, towards validating its broad pharmacol. claims. The phytochem. components of Yoyo bitters were ascertained by phytochem. screening assays and gas chromatog.-mass spectrometry (GC-MS). The antioxidant activity was investigated in vitro using 2,2-diphenyl-1-picryhydrazyl (DPPH) radical, hydrogen peroxide (H2O2) scavenging activity, total antioxidant capacity (TAC) and ferric reducing antioxidant power (FRAP) assays. Qual. phytochem. anal. of Yoyo bitters showed the presence of saponins, tannins, flavonoids, terpenoids, cardiac glycosides and anthocyanins. The total phenols, flavonoids, flavanols, tannins and carotenoids content were 14.741 ± 0.64 mg GAE/mL, 0.152 ± 0.01 mg RE/mL, 0.437 ± 0.02 mg RE/mL, 0.368 ± 0.04 mg TAE/mL and 0.016 ± 0.00 mg CAE/mL resp. GC-MS chromatogram revealed the presence of forty-three (43) phytochem. compounds with D-allose (41.81%), 1,6-anhydro-beta-D-glucofuranose (24.15%), 5-hydroxymethylfurfural (8.02%) and Z-6-pentadecen-1-ol acetate (3.50%) as the most abundant constituents. Yoyo bitters demonstrated effective antioxidant activity against DPPH and H2O2 with IC50 values of 0.492 mg/mL and 0.629 mg/mL resp. compared to ascorbic acid of 0.161 mg/mL and 0.130 mg/mL resp. Total antioxidant capacity and ferric reducing antioxidant power of Yoyo bitters were 0.432 mg AAE/mL and 2.236 mg AAE/mL resp. This study validates the antioxidant capacity of Yoyo bitters and provides chem. basis for its acclaimed pharmacol. actions.3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one) was used in this study.

3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) is a 5-membered cyclic ester. It was obtained via tin-conversion of biomass-derived 1,3-dihydroxyacetone (DHA) and formaldehyde. And it may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis.Recommanded Product: 3-Hydroxydihydrofuran-2(3H)-one

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem