Quality Control of 3-Hydroxydihydrofuran-2(3H)-oneOn September 1, 2021 ,《Depsipeptide nucleic acids: Prebiotic formation, oligomerization, and self-assembly of a new proto-nucleic acid candidate》 was published in Journal of the American Chemical Society. The article was written by Fialho, David M.; Karunakaran, Suneesh C.; Greeson, Katherine W.; Martinez, Isaac; Schuster, Gary B.; Krishnamurthy, Ramanarayanan; Hud, Nicholas V.. The article contains the following contents:
The mechanism by which informational polymers first formed on the early earth is currently unknown. The RNA world hypothesis implies that RNA oligomers were produced prebiotically, before the emergence of enzymes, but the demonstration of such a process remains challenging. Alternatively, RNA may have been preceded by an earlier ancestral polymer, or proto-RNA, that had a greater propensity for self-assembly than RNA, with the eventual transition to functionally superior RNA being the result of chem. or biol. evolution. We report a new class of nucleic acid analog, depsipeptide nucleic acid (DepsiPNA), which displays several properties that are attractive as a candidate for proto-RNA. The monomers of depsipeptide nucleic acids can form under plausibly prebiotic conditions. These monomers oligomerize spontaneously when dried from aqueous solutions to form nucleobase-functionalized depsipeptides. Once formed, these DepsiPNA oligomers are capable of complementary self-assembly and are resistant to hydrolysis in the assembled state. These results suggest that the initial formation of primitive, self-assembling, informational polymers on the early earth may have been relatively facile if the constraints of an RNA-first scenario are relaxed. The experimental part of the paper was very detailed, including the reaction process of 3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9Quality Control of 3-Hydroxydihydrofuran-2(3H)-one)
3-Hydroxydihydrofuran-2(3H)-one(cas: 19444-84-9) may be employed as starting reagent in the synthesis of series of seco-pseudonucleoside synthons via aminolysis. It may be employed as starting reagent in the synthesis of enantiomerically pure orthogonally protected δ-azaproline, via Mitsunobu reaction.Quality Control of 3-Hydroxydihydrofuran-2(3H)-one
Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem