Month: October 2022

Mikolas, Lena A; Jacques, Kimberly; Huq, Mostaqul; Krasner, Charles; Mambourg, Scott E published the artcile< Utilizing Clinical Pharmacist Specialist to Manage Hepatitis C Virus Patients on Direct-Acting Antiviral Therapy.>, HPLC of Formula: 58-97-9, the main research area is direct-acting antivirals; hepatitis C virus infection; liver disease; sustained virologic response.

OBJECTIVES: To evaluate outcomes of a clinical pharmacist specialist (CPS)-managed hepatitis C virus (HCV) treatment clinic (HCVTC) in treating HCV-infected veterans with direct-acting antivirals (DAAs). METHODS: We established a CPS-managed HCVTC under a collaborative practice agreement with our infectious disease physician (IDP). A total of 132 veterans were treated between November 1, 2014, and November 30, 2015. The CPS engaged in pretreatment screening, drug selection, patient education, medication counseling, drug therapy monitoring, drug utilization review, addressing issues on drug adherence, and routine and posttreatment follow-up of patients to assess sustained virologic response (SVR) after 12 weeks of treatment. RESULTS: Of 132 patients managed by the CPS, 87 (66%) were treated with ledipasvir/sofosbuvir (LDV/SOF), 29 (22%) with paritaprevir/ritonavir/ombitasvir + dasabuvir (PrOD), and 16 (12%) with sofosbuvir (SOF)-based regimen. The corresponding regimens demonstrated a SVR rate of 92% (n = 80), 100% (n = 29), and 93.8% (n = 15), respectively. We achieved an SVR rate of 94% against HCV genotype 1 (GT-1) and 100% against GT-2 to GT-4. The overall SVR rate was 94% across regimens, showing 93% in treatment-naive patients and 96% in treatment-experienced patients, and 93% in noncirrhotic and 94% in compensated cirrhotic patients. The results were comparable to SVR data reported in pivotal trials for DAAs. CONCLUSION: The results suggest that CPS could be effectively utilized in drug therapy management of HCV-infected patients treated with DAAs.

Journal of pharmacy practice published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, HPLC of Formula: 58-97-9.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Stucchi, Marta; Alijani, Sharam; Manzoli, Maela; Villa, Alberto; Lahti, Riikka; Galloni, M. G.; Lassi, Ulla; Prati, Laura published the artcile< A Pt-Mo hybrid catalyst for furfural transformation>, Product Details of C5H10O2, the main research area is platinum molybdenum catalyst furfural hydrogenation.

Furfural is a high-value chem., being the precursor of compounds such as furfuryl alc. and tetrahydrofurfuryl alc. Pt is known as active for furfural hydrogenation, but the high price limits its exploitation and imposes the search for alternatives. Here we presented a Pt/Mo bimetallic system with enhanced catalytic activity for furfural hydrogenation. For comparison, monometallic Mo- and Pt-supported on activated carbon have been prepared by impregnation and sol-immobilization. The bimetallic Pt/Mo was prepared impregnating the Mo-AC catalyst with Pt, using Na2PtCl4 as a precursor, PVA, and NaBH4 as reducing agent. HR-TEM analyses on Pt/Mo catalyst showed Mo-containing agglomerates embedded in the carbon matrix, displaying diffraction fringes with spacing typical of Mo4O11 in the orthorhombic phase, as well as Pt nanoparticles more evenly dispersed in the Mo-AC system compared to bare AC. The Pt/Mo catalyst showed higher activity than both monometallic ones, and it converted 92% of furfural to furfuryl alc. and Et furfuryl ether with 20% and 80% selectivity, resp. However, despite a lower initial activity, the monometallic Mo/AC catalyst showed a complete selectivity to the ether.

Catalysis Today published new progress about Binding energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Product Details of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Nakagawara, Kosuke; Takeuchi, Chieri; Ishige, Kazuya published the artcile< 5 ′-CMP and 5 ′-UMP promote myogenic differentiation and mitochondrial biogenesis by activating myogenin and PGC-1α in a mouse myoblast C2C12 cell line>, Product Details of C9H13N2O9P, the main research area is cytidinemonophosphate uridinemonophosphate myogenin PGCalpha myoblast myogenic differentiation mitochondrial biogenesis; 5′-CMP, Cytidine-5′-monophosphate; 5′-UMP, Uridine-5′-monophosphate; BS, Bovine serum; Cytidine-5′-monophosphate; Endurance; FBS, Fetal bovine serum; MRF, Myogenic regulatory factor; Mitochondria; MyHC, Myosin heavy chanin; Myogenic differentiation; Nutrition; Uridine-5′-monophosphate.

Ribonucleotides are basic monomeric building blocks for RNA considered as conditionally essential nutrients. They are normally produced in sufficient quantity, but can become insufficient upon stressful challenges. The administration of pyrimidine nucleotides, such as cytidine-5′-monophosphate (5′-CMP) and uridine-5′-monophosphate (5′-UMP), enables rats to endure prolonged exercise. However, the underlying mechanisms have remained elusive. To investigate these mechanisms, we studied the effect of 5′-CMP and 5′-UMP on muscular differentiation and mitochondrial biogenesis in myoblast C2C12 cells. A 5′-CMP and 5′-UMP were found to increase the mRNA levels of myogenin, which is a myogenic regulatory protein expressed during the final differentiation step and fusion of myoblasts into myotubes. The 5′-CMP and 5′-UMP also promoted myoblast differentiation into myotube cells. The 5′-CMP and 5′-UMP further increased the mRNA levels of PGC-1α which regulates mitochondrial biogenesis and skeletal muscle fiber type. In addition, 5′-CMP and 5′-UMP increased mitochondrial DNA copy number and enhanced mRNA levels of slow-muscle myosin heavy chains. Moreover, cytidine and uridine, nucleosides corresponding to 5′-CMP and 5′-UMP, markedly promoted myotube formation in C2C12 cells. Considering the metabolism and absorption of nucleotides, the active bodies underlying the effects observed with 5′-CMP and 5′-UMP could be cytidine and uridine. In conclusion, our results indicate that 5′-CMP and 5′-UMP can promote myogenic differentiation and mitochondrial biogenesis, as well as increase slow-twitch fiber via the activation of myogenin and PGC-1α. In addition, 5′-CMP and 5′-UMP may be considered as safe and effective agents to enhance muscle growth and improve the endurance in skeletal muscles.

Biochemistry and Biophysics Reports published new progress about Absorption. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Product Details of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Arumugam, Selvamani; Kuppan, Jayaprakash; Devaraj, Murugan; Arumugam, Sivasamy published the artcile< Fe-Pd-immobilized Al-pillared laponite clay as efficient catalyst for conversion of furfural into tetrahydrofurfuryl alcohol>, Name: (Tetrahydrofuran-2-yl)methanol, the main research area is iron palladium immobilized laponite hydrogenation catalyst furfural tetrahydrofurfuryl alc.

Furfural has been widely reported as a new-generation renewable source for the production of chems. and fuels. In this study, Fe-Pd immobilized Al-pillared laponite clay material with suitable catalytic properties was explored as an efficient catalyst for the direct conversion of furfural (FAL) into tetrahydrofurfuryl alc. (THFOL) under the mild reaction conditions (H2 pressure- 10 bar, temperature- 60°C and time- 4 h). The synthesized samples were characterized by several physico-chem. techniques. XRD, FT-IR, H2-TPR and ICP-OES results revealed the successful loading of those bi-metals into the Al-pillared laponite structure. Acidity of the sample has been thoroughly investigated by NH3-TPD and FT-IR techniques. The catalytic activity of synthesized samples was thoroughly evaluated for the total hydrogenation of FAL for the production of THFOL. It was observed that pure Fe-Pd catalyst showed very low FAL conversion (∼53%) and THFOL selectivity (∼38%), whereas the Al-pillared laponite clay supported Fe-Pd catalyst showed an increase in the FAL conversion and THFOL selectivity up to 95% and 98%, resp. The high performance of Fe-Pd/Al-pillared laponite catalyst towards the formation of THFOL is not only ascribed to the fine dispersion of Fe and Pd species and their synergistic effect but also due to the high surface area, mesoporosity and suitable acidity of Al-pillared laponite. The recyclability of the catalyst was also explored thoroughly which confirmed their stability. Sustainability of this process lies in the utilization of low-value bio-derived FAL for the production of industrially important THFOL chem.

ChemistrySelect published new progress about Hydrogenation. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Name: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Campisi, Sebastiano; Chan-Thaw, Carine E.; Chinchilla, Lidia E.; Chutia, Arunabhiram; Botton, Gianluigi A.; Mohammed, Khaled M. H.; Dimitratos, Nikolaos; Wells, Peter P.; Villa, Alberto published the artcile< Dual-Site-Mediated Hydrogenation Catalysis on Pd/NiO: Selective Biomass Transformation and Maintenance of Catalytic Activity at Low Pd Loading>, Application of C5H10O2, the main research area is hydrogenation catalysis palladium NiO biomass transformation.

Creating a new chem. ecosystem based on platform chems. derived from waste biomass has significant challenges; catalysts need to be able to convert these highly functionalized mols. to specific target chems., economical – not relying on large quantities of precious metals – and maintain activity over many cycles. Herein, we demonstrate how Pd/NiO is able to direct the selectivity of furfural hydrogenation and maintain performance at low Pd loading by a unique dual-site mechanism. Sol-immobilization was used to prepare 1 wt% Pd nanoparticles supported on NiO and TiO2, with the Pd/NiO catalyst showing enhanced activity with a significantly different selectivity profile; Pd/NiO favors tetrahydrofurfuryl alc. (72%), whereas Pd/TiO2 produces furfuryl alc. as the major product (68%). D. functional theory studies evidenced significant differences on the adsorption of furfural on both NiO and Pd surfaces. Based on this observation we hypothesized that the role of Pd was to dissociate hydrogen, with the NiO surface adsorbing furfural. This dual-site hydrogenation mechanism was supported by comparing the performance of 0.1 wt% Pd/NiO and 0.1 wt% Pd/TiO2. In this study, the 0.1 and 1 wt% Pd/NiO catalysts had a comparable activity, whereas there was a 10 fold reduction in performance for 0.1 weight% Pd/TiO2. When using TiO2 as the support the Pd nanoparticles are responsible for both hydrogen dissociation and furfural adsorption, and the activity is strongly correlated with the effective metal surface area. This work has significant implications for the upgrading of bio-derived feedstocks, suggesting alternative ways for promoting selective transformations and reducing the reliance on precious metals.

ACS Catalysis published new progress about Adsorption. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Application of C5H10O2.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Xu, Wenhua; Ma, Xiaoru; Su, Yuanhai; Song, Yang; Shang, Minjing; Lu, Xuemin; Lu, Qinghua published the artcile< Synthesis of highly transparent and thermally stable copolyimide with fluorine-containing dianhydride and alicyclic dianhydride>, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone, the main research area is transparent polyimide film material preparation alicyclic dianhydride diamine.

The development of optical films is highly desirable for applications in flexible displayers. In this work, a copolyimide (co-PI) film with high thermal stability and high transparency was prepared by the copolymerization of 2,2′-bis(trifluoromethyl)-4,4′-diaminodiphenyl ether, cyclobutanetetracarboxylic dianhydride, and 4,4′-(hexafluoroisopropylidene)diphthalic anhydride (6FDA). The effects of aliphatic dianhydride and fluorine dianhydride monomers on the optical, thermal, and mech. properties of the co-PIs were discussed in detail based on the exptl. results and theor. simulations. We found that the preparation of polyimide (PI) based on the combination of two dianhydrides could obtain the PI film with excellent comprehensive performance due to nonconjugated structure and strong electron-withdrawing effect. Through the structure and composition optimization, a PI film of PI-6FDA-70 with Tg of 300°C, Td10% more than 500°C, the average transparency of 90% and the elongation at the breakage more than 8% was prepared Such mol. design provides a practical approach to develop high-performance colorless PI films.

Journal of Applied Polymer Science published new progress about Contact angle. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, Recommanded Product: Cyclobuta[1,2-c:3,4-c’]difuran-1,3,4,6(3aH,3bH,6aH,6bH)-tetraone.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Serranti, Daniele; Dodi, Icilio; Nicastro, Emanuele; Cangelosi, Antonina M; Riva, Silvia; Ricci, Silvia; Bartolini, Elisa; Trapani, Sandra; Mastrangelo, Greta; Vajro, Pietro; D’Antiga, Lorenzo; Resti, Massimo; Indolfi, Giuseppe published the artcile< Shortened 8-Week Course of Sofosbuvir/Ledipasvir Therapy in Adolescents With Chronic Hepatitis C Infection.>, Application of C9H13N2O9P, the main research area is .

Treatment-naïve, noncirrhotic adults with chronic hepatitis C virus genotype 1 infection and with viremia levels <6 million IU/mL could be effectively treated with sofosbuvir/ledipasvir for 8 weeks. The aim of this pilot, prospective, open-label, multicenter study was to evaluate the efficacy and safety of this shortened treatment course in adolescents (≥12 years). The efficacy endpoint was sustained virological response 12 weeks after the end of treatment. Safety was assessed by adverse events and clinical/laboratory data. Fourteen consecutive adolescents (median age 16.5 years, Q1 14.1-Q3 17.4; female 57.1%), vertically infected, were enrolled and treated (June 2018-January 2019). Overall, the end of treatment response and sustained virological response 12 weeks after the end of treatment were 100%. No grade 3 to 4 adverse event or a serious adverse event was observed. Further studies are needed to confirm the optimal efficacy of the shortened 8-week treatment with sofosbuvir/ledipasvir for treatment-naïve, noncirrhotic adolescents with chronic hepatitis C virus genotype 1 infection and pretreatment viremia level < 6 million IU/mL. Journal of pediatric gastroenterology and nutrition published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Qingfei; Kuang, Gaizhen; He, Shasha; Liu, Sha; Lu, Hongtong; Li, Xiaoyuan; Zhou, Dongfang; Huang, Yubin published the artcile< Chain-shattering Pt(IV)-backboned polymeric nanoplatform for efficient CRISPR/Cas9 gene editing to enhance synergistic cancer therapy>, HPLC of Formula: 4415-87-6, the main research area is platinum polymeric nanoplatform CRISPR gene editing synergistic cancer therapy.

CRISPR/Cas9 system has become a promising gene editing tool for cancer treatment. However, development of a simple and effective nanocarrier to incorporate CRISPR/Cas9 system and chemotherapeutic drugs to concurrently tackle the biol. safety and packaging capacity of viral vectors and combine gene editing-chemo for cancer therapy still remains challenges. Herein, a chain-shattering Pt(IV)-backboned polymeric nanoplatform is developed for the delivery of EZH2-targeted CRISPR/Cas9 system (NPCSPt/pEZH2) and synergistic treatment of prostate cancer. The pEZH2/Pt(II) could be effectively triggered to unpack/release from NPCSPt/pEZH2 in a chain-shattering manner in cancer cells. The EZH2 gene disruption efficiency could be achieved up to 32.2% of PC-3 cells in vitro and 21.3% of tumor tissues in vivo, leading to effective suppression of EZH2 protein expression. Moreover, significant H3K27me3 downregulation could occur after EZH2 suppression, resulting in a more permissive chromatin structure that increases the accessibility of released Pt(II) to nuclear DNA for enhanced apoptosis. Taken together, substantial proliferation inhibition of prostate cancer cells and further 85.4% growth repression against s.c. xenograft tumor could be achieved. This chain-shattering Pt(IV)-backboned polymeric nanoplatform system not only provides a prospective nanocarrier for CRISPR/Cas9 system delivery, but also broadens the potential of combining gene editing-chemo synergistic cancer therapy.

Nano Research published new progress about Antitumor agents. 4415-87-6 belongs to class tetrahydrofurans, and the molecular formula is C8H4O6, HPLC of Formula: 4415-87-6.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Faraj, Osama Abdulrahman; AlBayati, Sabeha Moosa published the artcile< Assessment of outcome for sample of Iraqi patients with chronic hepatitis C virus infection treated by Ledipasvir/sofosbuvir drug.>, Application of C9H13N2O9P, the main research area is Hepatitis C virus, Ledipasvir/sofosbuvir, Iraq..

OBJECTIVE: To evaluate the response to treatment by the new directly acting antivirals drugs Sofosbuvir and Ledipasvir (Harvoni), on Iraqi patients diagnosed with hepatitis C infection genotype1 and genotype 4. METHODS: This prospective study was conducted in the Gastroenterology unit of Al- Yarmouk Teaching Hospital, Baghdad, Iraq, from February 2019 to February 2020. Included were one hundred patients diagnosed with hepatitis C by antibody test and viral load. All non-cirrhotic participants received a drug containing 400 mg sofosbuvir /90 mg ledipasvir once daily for 12 weeks, whereas the cirrhotics had to take it for 24 weeks. Laboratory Investigations and viral load were assessed at baseline, and twelve weeks after end of treatment. RESULTS: The predominant genotype was 1 with 58 (58 %) patients whereas genotype 4 had 42 (42%) patients. Liver cirrhosis was present in 9(9%) patients and severe renal impairment in 27(27%) patients. Undetectable viral load at the end of treatment (week 12) was observed in 96 (96%) patients whereas 4 (4%) patients were reported as non-responders. CONCLUSIONS: Excellent therapeutic results were achieved with generic combination of sofosbuvir/ledipasvir. The regimen is highly effective and tolerable with the highest viral response observed in HCV patients with genotype 1and 4, inclusive of patients with chronic renal failure or cirrhosis.

JPMA. The Journal of the Pakistan Medical Association published new progress about 58-97-9. 58-97-9 belongs to class tetrahydrofurans, and the molecular formula is C9H13N2O9P, Application of C9H13N2O9P.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Zhang, Jinxin; Mao, Donglei; Wu, Dongfang published the artcile< Industrially Applicable Aqueous-Phase Selective Hydrogenation of Furfural on an Efficient TiOx-Modified Ni Nanocatalyst>, Recommanded Product: (Tetrahydrofuran-2-yl)methanol, the main research area is industrially aqueous phase selective hydrogenation furfural titania nickel nanocatalyst.

Because water is involved in the formation of furfural (FFR), aqueous-phase selective hydrogenation of FFR to furfuryl alc. (FOL) has the potential for industrial applications, but it has not yet been well exploited. Here, partially reduced TiOx-modified Ni nanocatalysts were studied. The Ni-TiO2 interaction adjusts the Ni electron structure and affects the catalyst adsorption properties. FFR is adsorbed on the TiOx oxygen vacancy (OV) by C=O, and the FOL selectivity is pos. correlated with the surface OV content. The active H atoms dissociated on Ni spillover to the TiOx surface and then attack the adsorbed FFR C=O. The precise synergistic effect of Ni and OV improves the comprehensive performance of FFR hydrogenation. Under mild conditions, FFR conversion can reach 92.5% and FOL selectivity can be as high as 96.8%. This is an extremely excellent performance of aqueous-phase FFR selective hydrogenation, and thus, the TiOx-modified Ni nanocatalyst is a very promising candidate for industrial applications.

ACS Sustainable Chemistry & Engineering published new progress about Activation energy. 97-99-4 belongs to class tetrahydrofurans, and the molecular formula is C5H10O2, Recommanded Product: (Tetrahydrofuran-2-yl)methanol.

Referemce:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem