Jiangseubchatveera, Nadechanok;Bouillon, Marc E.;Liawruangrath, Boonsom;Liawruangrath, Saisunee;Nash, Robert J.;Pyne, Stephen G. published 《Concise synthesis of (-)-steviamine and analogues and their glycosidase inhibitory activities》 in 2013. The article was appeared in 《Organic & Biomolecular Chemistry》. They have made some progress in their research.Category: tetrahydrofurans The article mentions the following:
A concise synthesis of (-)-steviamine is reported along with the synthesis of its analogs 10-nor-steviamine, 10-nor-ent-steviamine and 5-epi-ent-steviamine. These compounds were tested against twelve glycosidases (at 143 μg mL-1 concentrations) and were found to have in general poor inhibitory activity against most enzymes. The 10-nor analogs however, showed 50-54% inhibition of α-l-rhamnosidase from Penicillium decumbens while one of these, 10-nor-steviamine, showed 51% inhibition of N-acetyl-β-d-glucosaminidase (from Jack bean) at the same concentration (760 μM). And (2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate (cas: 144490-03-9) was used in the research process.
(2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate(cas:144490-03-9 Category: tetrahydrofurans) is an isomer of 1,2,3,5-Tetra-O-acetyl β-D-Ribofuranose (T283100) which is used in the synthesis of 3-(β-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem