Chen, Tie-Gen;Barton, Lisa M.;Lin, Yutong;Tsien, Jet;Kossler, David;Bastida, Inaki;Asai, Shota;Bi, Cheng;Chen, Jason S.;Shan, Mingde;Fang, Hui;Fang, Francis G.;Choi, Hyeong-wook;Hawkins, Lynn;Qin, Tian;Baran, Phil S. published 《Building C(sp3)-rich complexity by combining cycloaddition and C-C cross-coupling reactions》. The research results were published in《Nature (London, United Kingdom)》 in 2018.Formula: C9H10O3 The article conveys some information:
Prized for their ability to rapidly generate chem. complexity by building new ring systems and stereocentres, cycloaddition reactions have featured in numerous total syntheses and are a key component in the education of chem. students. Similarly, carbon-carbon (C-C) cross-coupling methods are integral to synthesis because of their programmability, modularity and reliability. Within the area of drug discovery, an overreliance on cross-coupling has led to a disproportionate representation of flat architectures that are rich in carbon atoms with orbitals hybridized in an sp2 manner. Despite the ability of cycloadditions to introduce multiple carbon sp3 centers in a single step, they are less used. This is probably because of their lack of modularity, stemming from the idiosyncratic steric and electronic rules for each specific type of cycloaddition Here we demonstrate a strategy for combining the optimal features of these two chem. transformations into one simple sequence, to enable the modular, enantioselective, scalable and programmable preparation of useful building blocks, natural products and lead scaffolds for drug discovery. To complete the study, the researchers used (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) .
In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Formula: C9H10O3 It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem