Safety of (2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetateIn 2017, Amdouni, Hella;Robert, Guillaume;Driowya, Mohsine;Furstoss, Nathan;Metier, Camille;Dubois, Alix;Dufies, Maeva;Zerhouni, Marwa;Orange, Francois;Lacas-Gervais, Sandra;Bougrin, Khalid;Martin, Anthony R.;Auberger, Patrick;Benhida, Rachid published 《In Vitro and in Vivo Evaluation of Fully Substituted (5-(3-Ethoxy-3-oxopropynyl)-4-(ethoxycarbonyl)-1,2,3-triazolyl-glycosides as Original Nucleoside Analogues to Circumvent Resistance in Myeloid Malignancies》. 《Journal of Medicinal Chemistry》published the findings. The article contains the following contents:
A series of nucleoside analogs, e.g. I, bearing a 1,4,5-tri-substituted-1,2,3-triazole aglycon was synthesized using a straightforward click/electrophilic addition or click/oxidative coupling tandem procedures. SAR anal., using cell culture assays, led to the discovery of a series of compounds belonging to the 5-alkynyl-1,2,3-triazole family that exhibits potent antileukemic effects on several hematol. malignancies including chronic myeloid leukemia (CML) and myelodysplastic syndromes (MDS) either sensitive or resistant to their resp. therapy. Compound I also proved efficient in vivo on mice xenografted with SKM1-R MDS cell line. Addnl., some insights in its mode of action revealed that this compound can induce cell death by caspase and autophagy induction. To complete the study, the researchers used (2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate (cas: 144490-03-9) .
(2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate(cas:144490-03-9 Safety of (2R,3S,4S,5S)-5-(Acetoxymethyl)tetrahydrofuran-2,3,4-triyl triacetate) is an isomer of 1,2,3,5-Tetra-O-acetyl β-D-Ribofuranose (T283100) which is used in the synthesis of 3-(β-D-ribofuranosyl)-2,3-dihydro-6H-1,3-oxazine-2,6-dione, a new pyrimidine nucleoside analog related to uridine.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem