Ishizumi, Kikuo;Kojima, Atsuyuki;Antoku, Fujio published 《Synthesis and anxiolytic activity of N-substituted cyclic imides (1R*,2S*,3R*,4S*)-N-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-2,3-bicyclo[2.2.1]heptanedicarboximide (tandospirone) and related compounds》 in 1991. The article was appeared in 《Chemical & Pharmaceutical Bulletin》. They have made some progress in their research.Application of 14166-28-0 The article mentions the following:
A series of cyclic imides bearing ω-(4-aryl and 4-heteroaryl-1-piperazinyl)alkyl moieties, e.g., I, was synthesized and tested in vivo for anxiolytic activity. The in vitro binding affinities of these compounds were also examined for 5-HT1A receptor sites. Structure-activity relationships within the series are discussed. Tandospirone (I) was equipotent with buspirone in its anxiolytic activity and more anxio-selective than buspirone and diazepam. I is currently undergoing clin. evaluation as a selective anxiolytic agent.(3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione (cas: 14166-28-0) were involved in the experimental procedure.
In the laboratory, (3aR,4S,7R,7aS)-rel-Hexahydro-4,7-methanoisobenzofuran-1,3-dione(14166-28-0) is a popular solvent when its water miscibility is not an issue. It is more basic than diethyl ether and forms stronger complexes with Li+, Mg2+, and boranes.Application of 14166-28-0 It is a popular solvent for hydroboration reactions and for organometallic compounds such as organolithium and Grignard reagents.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem