So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Park, Kwanghee Koh; Jung, Jin Young researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Product Details of 20028-53-9.They published the article 《Facile synthesis of 3-substituted and 1,3-disubstituted quinolin-2(1H)-ones from 2-nitrobenzaldehydes》 about this compound( cas:20028-53-9 ) in Heterocycles. Keywords: quinolinone preparation; carboxamidobenzaldehyde preparation intramol cyclocondensation; aminobenzaldehyde acyl chloride amidation. We’ll tell you more about this compound (cas:20028-53-9).
2-Nitrobenzaldehydes were reduced with iron powder to 2-aminobenzaldehydes, which were reacted immediately with acyl chlorides to provide 2-carboxamidobenzaldehydes (I) with overall yields of 71-90 %. Subsequent reaction with base provided 3-substituted quinolin-2(1H)-ones with 63-97 % yields. Treatment of I with MeI and base gave 3-substituted 1-methylquinolin-2(1H)-ones with 82-95 % yields, whereas the treatment with Me2CHI gave 3-substituted 1-isopropylquinolin-2(1H)-ones with 7-42 % yields.
《Facile synthesis of 3-substituted and 1,3-disubstituted quinolin-2(1H)-ones from 2-nitrobenzaldehydes》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Amino-5-chlorobenzaldehyde)Product Details of 20028-53-9.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem