Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, N.I.H., Extramural, ACS Combinatorial Science called Cyanoacetamides (IV): Versatile One-Pot Route to 2-Aminoquinoline-3-carboxamides, Author is Wang, Kan; Herdtweck, Eberhardt; Domling, Alexander, which mentions a compound: 20028-53-9, SMILESS is NC1=CC=C(Cl)C=C1C=O, Molecular C7H6ClNO, SDS of cas: 20028-53-9.
Cyanoacetic acid derivatives are the starting materials for a plethora of multicomponent reaction (MCR) scaffolds. Herein, we describe scope of a valuable general protocol for the synthesis of arrays of 2-aminoquinoline-3-carboxamides from cyanoacetamides and 2-aminobenzaldehydes or heterocyclic derivatives via a Friedlaender reaction variation. In many cases, the reactions involve a very convenient work up by simple precipitation and filtration. More than 40 new products are described. We foresee our protocol and the resulting derivatives becoming very valuable to greatly expanding the scaffold space of cyanoacetamide derivatives
《Cyanoacetamides (IV): Versatile One-Pot Route to 2-Aminoquinoline-3-carboxamides》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Amino-5-chlorobenzaldehyde)SDS of cas: 20028-53-9.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem