Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Structure-activity relationship of xanthines and skeletal muscle ryanodine receptor/Ca2+ release channel.Application of 1028-33-7.
Caffeine activates in the millimolar range the skeletal muscle Ca2+ release channel (ryanodine receptor). Xanthine analogs substituted in the 1, 3, 7, 8, and 9 positions were tested for their capacity to increase [3H]ryanodine binding to skeletal muscle sarcoplasmic reticulum vesicles enriched in Ca2+ release activity and ryanodine receptor content. Of the 30 xanthines tested, 9 were more effective than caffeine in increasing [3H]ryanodine binding. The 7-Me group of caffeine was most important for activating the ryanodine receptor, followed by the Me groups in the 1 and 3 positions. An increase in hydrophobicity of the side chains in positions 7, 1, and 3 enhanced the ability of xanthines to activate the ryanodine receptor. Substitutions in positions 8 and 9 were without or with inhibitory effect.
《Structure-activity relationship of xanthines and skeletal muscle ryanodine receptor/Ca2+ release channel》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Application of 1028-33-7.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem