Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: Methyl 6-bromonicotinate, is researched, Molecular C7H6BrNO2, CAS is 26218-78-0, about Proximity effects in pyridines. Proton chemical shifts in substituted methyl pyridinecarboxylates.Related Products of 26218-78-0.
The chem. shifts in 6 series of substituted Me pyridinecarboxylates were measured and interpreted in terms of proximity effects. The shifts for ring H ortho and para to the substituent were explained by additive ester, nitrogen, and substituent effects. The results for meta H indicated substituent-nitrogen interactions, especially when both substituent and H were adjacent N. Similar results were obtained for the ester H.
This compound(Methyl 6-bromonicotinate)Related Products of 26218-78-0 was discussed at the molecular level, the effects of temperature and reaction time on the properties of the compound were discussed, and the optimum reaction conditions were selected.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem