Zhao, Dan; Shen, Qi; Zhou, Yu-Ren; Li, Jian-Xin published an article about the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9,SMILESS:NC1=CC=C(Cl)C=C1C=O ).Reference of 2-Amino-5-chlorobenzaldehyde. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:20028-53-9) through the article.
A facile alkenylation of quinazolines with unactivated terminal alkynes has been achieved in the presence of KOtBu without the aid of any transition metal catalysts. The reaction is carried out under very mild conditions and shows a high stereoselectivity. E.g., in presence of KOtBu in THF, alkenylation of quinazoline derivative (I) with PhCCH gave 89% (E)-II. A possible radical-based mechanism is also explored.
《KOtBu-mediated stereoselective addition of quinazolines to alkynes under mild conditions》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Amino-5-chlorobenzaldehyde)Reference of 2-Amino-5-chlorobenzaldehyde.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem