Ashford, Matthew W.; Xu, Chao; Molloy, John J.; Carpenter-Warren, Cameron; Slawin, Alexandra M. Z.; Leach, Andrew G.; Watson, Allan J. B. published an article about the compound: Methyl 6-bromonicotinate( cas:26218-78-0,SMILESS:C1=NC(=CC=C1C(=O)OC)Br ).Computed Properties of C7H6BrNO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:26218-78-0) through the article.
A catalytic enantioselective synthesis of heterocyclic vicinal fluoroamines such as I [Ar = Ph, 2-FC6H4, benzo[b]thiophenyl, etc.; Ar1 = quinolin-2-yl, quinoxalin-2-yl, benzo[d]thiazol-2-yl, etc.] is reported. A chiral Bronsted acid promotes aza-Michael addition to fluoroalkenyl heterocycles to give a prochiral enamine intermediate that undergoes asym. protonation upon rearomatization. The reaction accommodates a range of azaheterocycles and nucleophiles, generating C-F stereocenter in high enantioselectivity, and is also amenable to stereogenic C-CF3 bonds. Extensive DFT calculations provided evidence for stereocontrolled proton transfer from catalyst to substrate as rate-determining step, and showed importance of steric interactions from catalyst’s alkyl groups in enforcing high enantioselectivity. Crystal structure data show dominance of noncovalent interactions in core structure conformation, enabling modulation of conformational landscape. Ramachandran-type anal. of conformer distribution and Protein Data Bank mining indicated that benzylic fluorination by this approach has potential to improve potency of several marketed drugs.
The article 《Catalytic Enantioselective Synthesis of Heterocyclic Vicinal Fluoroamines by Using Asymmetric Protonation: Method Development and Mechanistic Study》 also mentions many details about this compound(26218-78-0)Computed Properties of C7H6BrNO2, you can pay attention to it, because details determine success or failure
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem