Name: 2-Amino-5-chlorobenzaldehyde. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about PPTS-Catalyzed Bicyclization Reaction of 2-Isocyanobenzaldehydes with Various Amines: Synthesis of Diverse Fused Quinazolines. Author is Meng, Xiang-He; Wu, Dan-Ni; Zhang, Yu-Jia; Zhao, Yu-Long.
A PPTS (pyridinium p-toluenesulfonate)-catalyzed bicyclization reaction of 2-isocyanobenzaldehydes 2-NC-4-R-5-R1C6H2CHO (R = H, Br, OMe; R1 = H, Cl, F, OMe) as 1,5-dielectrophiles with various amines R2NH2 (R2 = 3-hydroxypropyl, 2-amino-4,5-difluorophenyl, 2-(1H-pyrrol-1-yl)benzen-1-yl, etc.) has been developed. The reaction not only provides a simple and efficient strategy for the assembly of structurally diverse fused quinazoline derivatives e.g., I from readily available substrates under metal-free and mild conditions in a single step with only water and hydrogen as the byproducts, but also opens the way to the application of o-formyl arylisocyanides in the synthesis of nitrogen-containing heterocycles e.g., I.
Different reactions of this compound(2-Amino-5-chlorobenzaldehyde)Name: 2-Amino-5-chlorobenzaldehyde require different conditions, so the reaction conditions are very important.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem