Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3066-84-0, is researched, SMILESS is NC(N1)=NC(NC(Br)=N2)=C2C1=O, Molecular C5H4BrN5OJournal, Article, Research Support, Non-U.S. Gov’t, Research Support, U.S. Gov’t, Non-P.H.S., Research Support, U.S. Gov’t, P.H.S., Biochimica et Biophysica Acta, Gene Structure and Expression called Substrate and inhibitor specificity of tRNA-guanine ribosyltransferase, Author is Farkas, Walter R.; Jacobson, K. Bruce; Katze, Jon R., the main research direction is tRNA guanine ribosyltransferase specificity reticulocyte; structure activity tRNA guanine ribosyltransferase.Computed Properties of C5H4BrN5O.
A number of compounds, including derivatives of 7-deazaguanine, pteridines, purines, pyrimidines, and antimalarials were tested as inhibitors or substrates of tRNA-guanine ribosyltransferase (EC 2.4.2.29) (I). Virtually all purines and pteridines that were inhibitors or substrates of rabbit reticulocyte I had an amino N atom at the 2-position. In addition, the 9-position and the O atom at the 6-position may be important for recognition by the enzyme. Saturation of the double bond in the cyclopentenediol moiety of queuine (II) reduced the substrate activity and II analogs that lacked the cyclopentenediol moiety, such as 7-deazaguanine and 7-aminomethyl-7-deazaguanine, were relatively poor substrates for I. Adenosine was not an inhibitor of I and neoplanocin A (an adenosine analog in which a cyclopentenediol replaced the ribose moiety) was a poor inhibitor. The incorporation of 7-aminomethyl-7-deazaguanine into the tRNA of L-M cells resulted in a novel chromatog. form of tRNAAsp, indicating that L-M cells cannot modify this queuosone precursor (in Escherichia coli) to queuosine. The specific incorporation of 7-deazaguanine and 8-azaguanine into tRNA by L-M cells also resulted in novel chromatog. forms of tRNAAsp. With intact L-M cells, I-catalyzed insertion into tRNA of II, dihydro-II, 7-aminomethyl-7-deazaguanine, or 7-deazaguanine was irreversible, whereas guanine or 8-azaguanine incorporation was reversible, suggesting that it is the substitution of C-7 for N-7 which prevents the reversible incorporation of II into tRNA.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem