Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Conference, Vascular Dementia, International Congress, 3rd, Prague, Czech Republic, Oct. 23-26, 2003 called Non-human primate SPECT model for determining cerebral perfusion effects of cerebrovasoactive drugs acting via multiple modes of pharmacological action, Author is Oliver, D. W.; Dormehl, I. C.; Louw, W. K. A., which mentions a compound: 1028-33-7, SMILESS is CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O, Molecular C13H20N4O2, Electric Literature of C13H20N4O2.
Increasing clin. and exptl. evidence implicates cerebral hypoperfusion during increased aging and that cerebrovascular insufficiency is a vital component of the neuropathol. progression of dementia. This study describes a baboon Papio ursinus model under anesthesia, for in vivo cerebral blood flow (CBF) determinations, using Single Photon Emission Computed Tomog. (SPECT) following the split-dose method with 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO) and subsequent pharmacol. intervention studies. Studies were conducted with acetazolamide, pentifylline, nimodipine, sumatriptan and nicotinic acid. Increases in the cerebral perfusion of more than +30% were observed for nimodipine, acetazolamide and the combination of pentifylline and nicotinic acid. Drug interaction studies revealed an attenuation of increased CBF with sumatriptan or acetazolamide in combination with nimodipine. The CBF non-human primate model is therefore useful for the investigation of vasoactive drugs in dementia, acting via various pharmacol. modes of action.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem