Klotz, U.; Vapaatalo, H. published an article about the compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione( cas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O ).SDS of cas: 1028-33-7. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:1028-33-7) through the article.
Cyclic nucleotide phosphodiesterase (I) [9040-59-9] partly purified from rat diaphragm had a pH optimum of 7.0-8.0 and showed 2 apparent Km values for 3′,5′-cyclic AMP [60-92-4] hydrolysis in the low and high substrate concentration ranges, resp. Various pharmaceuticals inhibited I noncompetitively in the order eupaverin [1163-37-7] ≥ papaverine-HCl [61-25-6] > 1-hexyl-3,7-dimethylxanthine [1028-33-7] > Ro 7-2956 [26772-42-9] > theophylline [58-55-9] > d-tubocurarine chloride [57-94-3] > hydrochlorothiazide [58-93-5]. I was competitively inhibited by N6,2′-O-dibutyryl cyclic AMP [362-74-3] and cyclic GMP [7665-99-8] and noncompetitively by cyclic IMP [3545-76-4]. The mode of action of these drugs might be facilitation of the release of acetylcholine from motor nerve endings via the accumulation of cyclic AMP.
The article 《Rat diaphragm cyclic nucleotide phosphodiesterase. Influence of drugs affecting skeletal muscle contractility》 also mentions many details about this compound(1028-33-7)SDS of cas: 1028-33-7, you can pay attention to it, because details determine success or failure
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem