The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Base-modified GDP-mannose derivatives and their substrate activity towards a yeast mannosyltransferase, the main research direction is nucleobase modification GDP mannose derivative recognition mannosyltransferase Kre2p; Donor analogue; Mannosyltransferase; NDP-mannose; Substrate.Product Details of 3066-84-0.
We have previously developed a new class of inhibitors and chem. probes for glycosyltransferases (GTs) through base-modification of the sugar-nucleotide donor. The key feature of these donor analogs is the presence of an addnl. substituent at the nucleobase. To date, the application of this general concept has been limited to UDP-sugars and UDP-sugar-dependent glycosyltransferases. Herein, we report for the first time the application of our approach to a GDP-mannose-dependent mannosyltransferase (ManT). We have prepared four GDP-mannose derivatives with an addnl. substituent at either position 6 or 8 of the nucleobase. These donor analogs were recognized as donor substrates by the mannosyltransferase Kre2p from yeast, albeit with significantly lower turnover rates than the natural donor GDP-mannose. The presence of the addnl. substituent also redirected enzyme activity from glycosyl transfer to donor hydrolysis. Taken together, our results suggest that modification of the donor nucleobase is, in principle, a viable strategy for probe and inhibitor development against GDP-mannose-dependent GTs.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem