Reference of 2-Amino-5-chlorobenzaldehyde. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Heterogeneous synergistic catalysis for promoting Aza-Michael-Henry tandem reaction for the synthesis of chiral 3-nitro-1,2-dihydroquinoline. Author is An, Zhe; Chen, Lifeng; Jiang, Yitao; He, Jing.
Heterogeneous synergistic catalysis by SBA-15 immobilized chiral amines catalysts has promoted efficient aza-Michael-Henry tandem reaction for the synthesis of chiral 3-nitro-1,2- dihydroquinolines (S)-I (R = Ph, 2,3-dimethoxyphenyl, 3,4-dichlorophenyl, etc.; R1 = H, 8-MeO, 6-Cl, 6,8-Br2). Final products in the asym. aza-Michael-Henry cascade reactions between 2-aminobenzaldehydes R2-2-H2NC6H3CHO (R2 = H, 3-MeO, 5-Cl, 3,5-Br2) and β-nitrostyrenes RCH=CHNO2 were afforded in a yield of 85% and an enantiomeric excess (ee) value of 98% on (S)-(-)-2-aminomethyl-1-ethylpyrrolidine immobilized SBA-15. SBA-15-AEP catalyst has been also extended to the asym. aza-Michael-Henry cascade reaction of substituted 2-aminobenzaldehydes and substituted nitroolefins. The heterogeneous synergistic mechanism for both tertiary amine and secondary amine immobilized mesoporous has been proposed in detail including the geometrical constraints in the ee promotion.
The article 《Heterogeneous synergistic catalysis for promoting Aza-Michael-Henry tandem reaction for the synthesis of chiral 3-nitro-1,2-dihydroquinoline》 also mentions many details about this compound(20028-53-9)Reference of 2-Amino-5-chlorobenzaldehyde, you can pay attention to it, because details determine success or failure
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem