Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Research Support, Non-U.S. Gov’t, Journal of Organic Chemistry called Recognition in Chiral Ionic Liquids: The Achiral Cation Makes the Difference!, Author is Blasius, Jan; Zaby, Paul; Holloczki, Oldamur; Kirchner, Barbara, which mentions a compound: 4221-99-2, SMILESS is C[C@H](O)CC, Molecular C4H10O, COA of Formula: C4H10O.
By simulating butan-2-ol dissolved in the chiral ionic liquid 1-ethyl-3-methylimidazolium (S)-alaninate, we investigate the chiral recognition of butan-2-ol in the ionic liquid The hydrogen bonding between the chiral anion and both enantiomers of butan-2-ol is similar; however, both chiral mols. (anion and alc.) induce an asymmetry in the achiral cation which leads to a more favorable environment for the alc. in the heterochiral system as compared to the homochiral system and hence provides an energetic stabilization of the former.
After consulting a lot of data, we found that this compound(4221-99-2)COA of Formula: C4H10O can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem