Xiong, Zhiling; Zhang, Xinhang; Li, Yangming; Peng, Xiaoshi; Fu, Jiayue; Guo, Jiajia; Xie, Fukai; Jiang, Chongguo; Lin, Bin; Liu, Yongxiang; Cheng, Maosheng published the article 《Syntheses of 12H-benzo[a]xanthen-12-ones and benzo[a]acridin-12(7H)-ones through Au(I)-catalyzed Michael addition/6-endo-trig cyclization/aromatization cascade annulation》. Keywords: benzoxanthenone preparation benzoacridinone; diphenylpropynone preparation Michael endo trig cyclization aromatization gold catalyst; ethynyl methoxyvinyl benzene diastereoselective preparation benzaldehyde nucleophilic addition oxidation; trimethylsilyl ethynyl benzaldehyde preparation Wittig desilylation; benzaldehyde ethynyl trimethylsilane Sonogashira coupling palladium catalyst.They researched the compound: 2-Amino-5-chlorobenzaldehyde( cas:20028-53-9 ).Reference of 2-Amino-5-chlorobenzaldehyde. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:20028-53-9) here.
A multifaceted gold(I)-catalyzed Michael addition/6-endo-trig cyclization/aromatization cascade annulation strategy to synthesize both 12H-benzo[a]xanthen-12-ones I [R1 = H, 9-Me, 10-MeO, etc.; R2 = H, 3-F, 3-Cl, 3-MeO] and benzo[a]acridin-12(7H)-ones II, as important scaffolds in an immense number of bioactive compounds, was developed. The scopes of this strategy were examined by employment of a batch of synthetic 1,3-diphenylprop-2-yn-1-one substrates. To probe the mechanism of this cyclization a control experiment for intermediates synthesis was performed. Thus, a putative mechanism was determined according to this experiment and previous studies.
After consulting a lot of data, we found that this compound(20028-53-9)Reference of 2-Amino-5-chlorobenzaldehyde can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem