Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 3066-84-0, is researched, SMILESS is NC(N1)=NC(NC(Br)=N2)=C2C1=O, Molecular C5H4BrN5OJournal, Article, Research Support, U.S. Gov’t, P.H.S., Journal of Immunology called Role of salvage and phosphorylation in the immunostimulatory activity of C8-substituted guanine ribonucleosides, Author is Goodman, Michael G., the main research direction is C8 substituted guanine ribonucleoside immunostimulation; purine salvage phosphorylation guanine nucleoside immunostimulation.Synthetic Route of C5H4BrN5O.
Lymphokine-like activity and selective stimulation of B cell growth is exerted by a group of synthetic ribonucleosides derivatized at C8 and exemplified by 8-bromoguanosine (8BrGuo), 8-mercaptoguanosine, and 7-methyl-8-oxoguanosine. Here, it is demonstrated that, in contrast to naturally occurring nucleosides, 8BrGuo is not a substrate for salvage by purine nucleoside phosphorylase. The base that would be produced by putative phosphorolysis, 8-bromoguanine, is biol. inactive and is not a substrate for hypoxanthine-guanine phosphoribosyltransferase. Inhibitors of purine nucleoside phosphorylase-mediated salvage fail to inhibit nucleoside-induced immunostimulation selectively. There is no direct evidence that 8BrGuo is phosphorylated by B lymphocytes. Direct enzymic phosphorylation does not seem to be essential to the mechanism of action of the nucleoside insofar as competitive inhibition of deoxycytidine kinase (an enzyme that directly phosphorylates purines as well as pyrimidines) or of deoxyguanosine kinase fails to inhibit 8BrGuo stimulation selectively. Studies with synthetic nucleosides in which 3′ and/or 5′ hydroxyl groups were irreversibly blocked, precluding their phosphorylation, demonstrated that immunol. activity can occur in the absence of 3′ and/or 5′ phosphorylation. Experiments with radiolabeled nucleosides provide no evidence to support the hypothesis that they are incorporated into cellular nucleic acid. Apparently, it is the unmetabolized nucleoside that is active and, as such, is most likely to act in a regulatory capacity.
After consulting a lot of data, we found that this compound(3066-84-0)Synthetic Route of C5H4BrN5O can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem