The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate( cas:51856-79-2 ) is researched.Product Details of 51856-79-2.Reddy, Lekkala Amarnath; Chakraborty, Saurya; Swapna, Rodda; Bhalerao, Dinesh; Malakondaiah, Golla China; Ravikumar, Mylavarapu; Kumar, Abhijeet; Reddy, Gade Srinivas; Naram, Jyothirmayi; Dwivedi, Namrata; Roy, Arnab; Himabindu, Vurimidi; Babu, Bangaru; Bhattacharya, Apurba; Bandichhor, Rakeshwar published the article 《Synthesis and Process Optimization of Amtolmetin: An Antiinflammatory Agent》 about this compound( cas:51856-79-2 ) in Organic Process Research & Development. Keywords: amtolmetin intermediate tolmetin preparation electrophilic substitution reduction optimization. Let’s learn more about this compound (cas:51856-79-2).
Efforts toward the synthesis and process optimization of amtolmetin guacil (1) are described. High-yielding electrophilic substitution followed by Wolff-Kishner reduction are the key features in the synthesis of tolmetin, which is an advanced intermediate of 1.
After consulting a lot of data, we found that this compound(51856-79-2)Product Details of 51856-79-2 can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem