The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Viruses grown in the presence of base analogs. Specific alteration of susceptibility to inactivation by radiations, mutagens, and photodyes》. Authors are Thiry, Lise.The article about the compound:8-Bromoguaninecas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O).Recommanded Product: 8-Bromoguanine. Through the article, more information about this compound (cas:3066-84-0) is conveyed.
Newcastle disease (NDV) and Western equine encephalomyelitis (WEE) viruses, were grown in the presence of various base analogs, and their sensitivity to inactivation by nitrous acid, dimethyl sulfate, hydroxylamine, uv and visible light, as well as to photosensitization by several dyes was examined The slopes of the inactivation curves were compared with those obtained with normal viruses. Viruses grown in the presence of 2,6-diaminopurine or 5-aminouridine were specifically hypersensitized to nitrous acid; those grown in the presence of 6-thiopurines became sensitive to visible light. Growth in the presence of 6-azauridine, dihydrouracil, and, to a lesser degree, 6-azacytidine plus deoxycytidine, induced an increased resistance to uv light. This was paralleled by increased resistance to photosensitization by toluidine blue, neutral red, proflavine, and ethidium chloride, but not by methylene blue. An increased susceptibility to the action of the first 4 dyes was observed with viruses grown in the presence of 5-fluorouracil and 2-thiouracil at concentrations of the analogs which did not modify the viral susceptibility to uv light. Viruses formed in the presence of 8-azaguanine and 8-bromoguanine were hypersusceptible to dimethyl sulfate and methylene blue, reagents known to react preferentially with guanine. When inosine plus an inhibitor of xanthine oxidase was added to the growth medium, the progeny of infective particles was hypersusceptible to dimethyl sulfate. The results show that infectious virus particles with a modified nucleic acid were produced in the presence of the base analogs cited above. The specificity of the modifications found suggests that the analogs were incorporated per se in the nucleic acid chain of the virus.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem