Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Zhongguo Tiaoweipin called A new method for synthesis of monomenthyl succinate, Author is Chen, Lei; Yan, Rian; Du, Shuxia; Huang, Caihuan; Duan, Hanying; Liu, Yanqiong, which mentions a compound: 77341-67-4, SMILESS is CC(C)[C@@H]1CC[C@@H](C)C[C@H]1OC(=O)CCC(O)=O, Molecular C14H24O4, Recommanded Product: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.
The method is dissolving menthol and succinic anhydride in chloroform according to some proportion, and reacting under catalyzing by 4-DMAP at 50°C for 12 h, washing the product with saturated NaCl solution, then drying with anhydrous bitter salt and concentrating Monomenthyl succinate was obtained when the condensate was purified with silica gel chromatog. It’s m.p. is 61-63°C. Monomenthyl succinate was proved by IR spectrum and MS. New method for synthesis of monomenthyl succinate is provided by this research.
After consulting a lot of data, we found that this compound(77341-67-4)Recommanded Product: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem