Safety of 8-Bromoguanine. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Functional groups on ‘Z’ DNA recognized by monoclonal antibodies. Author is Lee, Jeremy S.; Woodsworth, Mary L.; Latimer, Laura J. P..
Both brominated poly[d(GC)] and poly[d(Gm5C), where m5C = 5-methylcytidylate] form stable left-handed Z-DNA structures at physiol. ionic strengths. These 2 antigens were used to prepare monoclonal antibodies from immunized mice. The specificity of the antibodies was studied in detail with a solid-phase radioimmune assay as well as by competition experiments Both immunogens produced several relatively nonspecific antibodies, but 2 types of very specific antibody were also distinguished. The 1st binds poly[d(Gm5C)] but not brominated poly[d(GC)], whereas the other has the opposite specificity and will only bind the brominated polymer. In these studies, monoclonal antibodies are used as model proteins for Z DNA functional group recognition.
Although many compounds look similar to this compound(3066-84-0)Safety of 8-Bromoguanine, numerous studies have shown that this compound(SMILES:NC(N1)=NC(NC(Br)=N2)=C2C1=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem