Category: tetrahydrofurans. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Activation of murine lymphocytes by cyclic guanosine 3′,5′-monophosphate: specificity and role in mitogen action. Author is De Rubertis, Frederick R.; Zenser, Terry.
Cyclic GMP and guanosine modestly increased the incorporation of thymidine-3H into DNA by cultured mouse spleen lymphocytes, but were far less effective than their 8-bromo(Br) derivatives However, on a molar basis the mitogenic activity of both 8-Br-guanosine and 8-Br-5′-GMP exceeded that of 8-Br-cyclic GMP, when tested in the presence and absence of serum in the culture media. Combined addition of maximal doses of these nucleotides did not give additive stimulatory effects, suggesting an action on a common subpopulation of cells, and possibly a common mechanism. By contrast, cyclic AMP, 8-Br-cyclic AMP, 8-Br-adenosine, cholera toxin and prostaglandin E1 suppressed both basal thymidine-3H incorporation and stimulation of this parameter by T-cell mitogens and the guanine nucleotides. Rapid effects of concanavalin A, phytohemagglutinin, SEB (staphylococcal enterotoxin B), guanosine, 5′-GMP, 8-Br-guanosine, and 8-Br-5′-GMP on the cyclic GMP content of murine lymphocytes could not be demonstrated. Similarly, concanavalin A, phytohemagglutinin and SEB failed to alter guanylate cyclase activity when added directly to cellular homogenates or preincubated with intact cells. Conversely, carbamylcholine rapidly increased lymphocyte cyclic GMP but was not mitogenic. Apparently, cyclic GMP and cyclic AMP are antagonistic in their influence on lymphocyte mitogenesis.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem