Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Non-human primate SPECT model for determining cerebral perfusion effects of cerebrovasoactive drugs acting via multiple modes of pharmacological action. Author is Oliver, Douglas W.; Dormehl, Irene C.; Louw, Werner K. A..
Increasing clin. and exptl. evidence implicate cerebral hypoperfusion during increased aging and points to chronic cerebrovascular ischemia as a vital component of the neuropathol. progression of dementia. In vivo cerebral perfusion animal models can greatly contribute to the evaluation of drugs and to the screening of drug interactions. This study describes a baboon Papio ursinus model under anesthesia, for in vivo cerebral blood flow (CBF) determinations, using Single Photon Emission Computed Tomog. (SPECT) following the split-dose method with 99mTc-hexamethylpropylene amine oxime (99mTc-HMPAO). Perfusion studies with acetazolamide as intervention clearly showed that the non-human primate model under aneasthesia is sufficiently sensitive to serve in the evaluation of other cerebrovasoactive drugs for induced perfusion changes with significant increases of the R-value (+40%) for comparative measurement when compared to the control value (2.53±0.15 vs. 1.79±0.13). These findings stimulated investigations of several drugs, i.e. pentifylline (phosphodiesterase inhibitor); nimodipine (calcium channel blocker); sumatriptan (serotonin receptor agonist) and nicotinic acid (vasodilator) for CBF effects. Increases in the cerebral perfusion in some cases more than +30% for nimodipine (2.51±0.14 vs. 1.79±0.13), acetazolamide and +29% for the combination of pentifylline and nicotinic acid (2.31±0.19 vs. 1.79±0.13) were observed Drug interaction studies revealed an attenuation of increased CBF due to nimodipine, with sumatriptan (-25%) and acetazolamide (+22%) in combination with nimodipine. Drug interactions with clin. implications may result during simultaneous use of cerebrovasoactive drugs in managing patients with cerebrovascular disorders. This study further showed that the CBF non-human primate model under anesthesia is useful for the investigation of vasoactive drugs acting via various pharmacol. modes of action.
Although many compounds look similar to this compound(1028-33-7)Recommanded Product: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, numerous studies have shown that this compound(SMILES:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem