In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Synthesis of 6- and 8-alkynylated purines and their ribonucleosides by the coupling of halopurines with alkynes, published in 1982, which mentions a compound: 3066-84-0, mainly applied to alkynylated purine; nucleotide alkynylated purine; alkynylation purine; coupling halopurine alkyne; cytokinin activity alkynylated purine, Recommanded Product: 3066-84-0.
Coupling reactions of 6-iodo- or 6-chloropurine with alkynes in the presence of (PPh3)2PdCl2-CuI catalyst in Et3N to give 6-alkynylated purines was achieved by the use of dipolar aprotic solvent as cosolvent. Under the reaction conditions, ribonucleoside as well as its tri-O-acetate of 6-chloropurine also gave the corresponding alkynylated products in high yields. Though similar reaction for 8-bromo derivatives of adenineand guanine gave poor yields, the 8-alkynylated free bases could be obtained by acid hydrolysis of the alkynylated ribonucleosides. 6-Alkynylated purines exhibited moderate to weak cytokinin activity in Amaranthus test.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem