The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate(SMILESS: O=C(OC)CC1=CC=CN1C,cas:51856-79-2) is researched.Formula: C13H20N4O2. The article 《Water-compatible cycloadditions of oligonucleotide-conjugated strained allenes for DNA-encoded library synthesis》 in relation to this compound, is published in ChemRxiv. Let’s take a look at the latest research on this compound (cas:51856-79-2).
DNA-encoded libraries of small mols. are being explored extensively for the identification of binders in early drug-discovery efforts. Combinatorial syntheses of such libraries require water- and DNA-compatible reactions, and the paucity of these reactions currently limit the chem. features of resulting barcoded products. The present work introduces strain-promoted cycloadditions of cyclic allenes under mild conditions to DNA-encoded library synthesis. Owing to distinct cycloaddition modes of these reactive intermediates with activated olefins, 1,3-dipoles and dienes, the process generates diverse mol. architectures from a single precursor. The resulting DNA-barcoded compounds exhibit unprecedented ring and topog. features-related to elements found to be powerful in phenotypic screening.
Although many compounds look similar to this compound(51856-79-2)Reference of Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, numerous studies have shown that this compound(SMILES:O=C(OC)CC1=CC=CN1C), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem