Goodman, Michael G.; Weigle, William O. published an article about the compound: 8-Bromoguanine( cas:3066-84-0,SMILESS:NC(N1)=NC(NC(Br)=N2)=C2C1=O ).Quality Control of 8-Bromoguanine. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:3066-84-0) through the article.
8-Bromoguanosine (88rGuo), a low mol.weight nucleoside derivative that rapidly traverses the lymphocyte membrane to the interior of the cell, is an extremely potent inducer of Ig production by B lymphocytes. 88Br-cGMP and other cGMP analogs are at best weak inducers of Ig secretion, being >2 orders of magnitude less effective (per mol. taken up) then 8BrGuo. Incubation of lymphocytes with 88rGuo fails to elevate their intracellular concentrations of cGMP. Moreover, at equimolar concentrations, underivatized cGMP actually antagonizes the induction of antibody production by 8BrGuo. These data, in concert with observations that many lymphocyte activators fail to alter cGMP content, that many agents that elevate cGMP fail to induce Ig synthesis, and that some cGMP-elevating agents even inhibit it, suggest that the induction of proliferation in B cells, is not primarily dependent upon cGMP. A simple nucleoside derivative is described, the use of which should prove to be a powerful probe for investigating the triggering mechanisms underlying the proliferative and differentiative B lymphocyte pathways at the mol. level.
Although many compounds look similar to this compound(3066-84-0)Quality Control of 8-Bromoguanine, numerous studies have shown that this compound(SMILES:NC(N1)=NC(NC(Br)=N2)=C2C1=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem