Analyzing the synthesis route of 20028-53-9

Although many compounds look similar to this compound(20028-53-9)Electric Literature of C7H6ClNO, numerous studies have shown that this compound(SMILES:NC1=CC=C(Cl)C=C1C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Amino-5-chlorobenzaldehyde, is researched, Molecular C7H6ClNO, CAS is 20028-53-9, about Metal-free synthesis of quinolines catalyzed by carbon aerogels: Influence of the porous texture and surface chemistry, the main research direction is synthesis quinoline carbon aerogel catalyst porous texture surface chem; Friedlander reaction catalyst aminochlorobenzaldehyde Et acetoacetate.Electric Literature of C7H6ClNO.

We report herein an exptl. and theor. study of the Friedlander reaction, from 2-amino-5-chlorobenzaldehyde and Et acetoacetate, catalyzed by free-metal nanocatalysts based on carbon aerogels, to afford quinoline 3a. The developed methodol. implies the combined use of carbon aerogels with solvent-free technologies under MW irradiation yielding the corresponding quinoline with moderated yield (66%) in only 5 min of reaction time. Our results demonstrated that the reactivity of the samples upon MW irradiation is strongly dependent on the porosity and surface chem. of the carbon aerogels, the most active catalytic species being the most acidic oxygenated functional groups, -CO2H groups originated by oxidant treatment, or even in situ by hydrolysis of -CO-O-CO-, over the carbon surface. The theor. investigation of the reaction mechanism, by using computational methods, demonstrated that the synthesis of quinoline 3a in the absence or in the presence of carbon aerogels takes place by aldolization, subsequent heterocyclization and finally double dehydration. Relatively strong π-π stacking interactions between carbon support and reagents could be behind of the observed catalytic performance also extended for the oxygenated models. Furthermore, the concentration of -CO2H groups over the carbon surface is a key factor favoring each step of the reaction but acting as individual catalytic sites.

Although many compounds look similar to this compound(20028-53-9)Electric Literature of C7H6ClNO, numerous studies have shown that this compound(SMILES:NC1=CC=C(Cl)C=C1C=O), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem