Simple exploration of 77341-67-4

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Koseki, Yoshitaka; Ikuta, Yoshikazu; Cong, Liman; Takano-Kasuya, Mayumi; Tada, Hiroshi; Watanabe, Mika; Gonda, Kohsuke; Ishida, Takanori; Ohuchi, Noriaki; Tanita, Keita; Taemaitree, Farsai; Dao, Anh Thi Ngoc; Onodera, Tsunenobu; Oikawa, Hidetoshi; Kasai, Hitoshi researched the compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ).Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.They published the article 《Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity》 about this compound( cas:77341-67-4 ) in Bulletin of the Chemical Society of Japan. Keywords: prodrug SN38 hydrophobicity cancer antitumor. We’ll tell you more about this compound (cas:77341-67-4).

In the field of drug delivery, controllability of drug release site and duration are among the most important factors to manipulate the drug efficacy and side effects. In this paper, a series of nano-prodrugs (NPs) composed of anticancer agent SN-38 and various substituent groups were synthesized and fabricated. By increasing the hydrophobicity of the prodrug mol. (calculated logP values exceeded ca. 7) through changing the substituent group, the hydrolysis susceptibility of SN-38 NPs in mouse serum was drastically decreased, thus prolonged the blood retention time of the NPs. In light of this knowledge and the dispersion stability in aqueous media, SN-38 NP modified with cholesterol (SN-38-chol NPs) was selected to be the optimal candidate among the screened NPs. The in vivo pharmacol. effect of SN-38-chol NP was about 10 times higher than irinotecan, the clin. used solubilized prodrug analog of SN-38. In addition, SN-38-chol NP has low side effects in evaluating intestinal damage. These NPs possess great potential for clin. application and promise to be a next-generation of drug for cancer treatment.

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem