Product Details of 51856-79-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Synthesis and antifungal activity of some new 1,2,4-triazole and furan containing compounds. Author is Shehata, Ihsan A..
Several new 1,2,4-triazole analogs attached to substituted Ph, pyrrole or furan 5-membered heterocycles were synthesized and screened for their antimicrobial activity. Bromination of Me 2-methylfuran-3-carboxylate, followed by ring closure with aniline, gave 5,6-dihydro-4-oxo-5-phenyl-4H-furo[2,3-c]pyrrole (I) in 55% yield (two steps). Compounds I and 3-(1-methyl-2-pyrrolylmethyl)-4-phenyl-5-(4-chlorophenylcarbamoylmethylthio)-1,2,4-triazole showed a prominent activity against C. albicans and S. cerevisiae.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem