Gilissen, Pieter J.; Slootbeek, Annemiek D.; Ouyang, Jiangkun; Vanthuyne, Nicolas; Bakker, Rob; Elemans, Johannes A. A. W.; Nolte, Roeland J. M. published the article 《Enantioselective synthesis of chiral porphyrin macrocyclic hosts and kinetic enantiorecognition of viologen guests》. Keywords: chiral porphyrin preparation enantioselective kinetic enantiorecognition viologen guest.They researched the compound: (S)-Butan-2-ol( cas:4221-99-2 ).Related Products of 4221-99-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4221-99-2) here.
The asym. synthesis of two enantiomeric C2-sym. porphyrin macrocyclic hosts (R,R,R,R)/(S,S,S,S)-I that thread and bind different viologen guests is described. Time-resolved fluorescence studies show that these hosts display a factor 3 kinetic preference (ΔΔGon = 3 kJ mol-1) for threading onto the different enantiomers of a viologen guest appended with bulky chiral 1-phenylethoxy termini. A smaller kinetic selectivity (ΔΔGon = 1 kJ mol-1) is observed for viologens equipped with small chiral sec-butoxy termini. Kinetic selectivity is absent when the C2-sym. hosts are threaded onto chiral viologens appended with chiral tails in which the chiral moieties are located in the centers of the chains, rather than at the chain termini. The reason is that the termini of the latter guests, which engage in the initial stages of the threading process (entron effect), cannot discriminate because they are achiral, in contrast to the chiral termini of the former guests. Finally, the experiments show that the threading and de-threading rates are balanced in such a way that the observed binding constants are highly similar for all the investigated host-guest complexes, i.e. there is no thermodn. selectivity.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem