Day: April 14, 2022

Application In Synthesis of (S)-Butan-2-ol. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Preliminary exploration on enzyme-promoted asymmetric biomimetic synthesis of resveratrol dimers. Author is Lei, Tian; Guan, Xingchao; Kang, Xiaodong; Wang, Yuefei; Han, Li; Li, Wenling.

The asym. biomimetic synthesis of resveratrol dimers was preliminarily explored using the enzyme-mediated oxidative coupling reactions of chiral resveratrol derivatives as the key step. The horseradish peroxidase-H2O2-promoted oxidations of 11,13-di-sec-butylresveratrol ether and 3,5-dibromoresveratrol di-sec-Bu ethers generated an 8-5-coupled intermediate and several 8-8-coupled dimeric mixtures, resp. The acid-catalyzed debutylation of the coupling dimers and hydrogenolytic debromination synthesized natural (+)-δ-viniferin (I) and unnatural (+)-isoquadrangularin A (II) with undetermined stereoisomer ratio.

Compounds in my other articles are similar to this one((S)-Butan-2-ol)Application In Synthesis of (S)-Butan-2-ol, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Gilissen, Pieter J.; Slootbeek, Annemiek D.; Ouyang, Jiangkun; Vanthuyne, Nicolas; Bakker, Rob; Elemans, Johannes A. A. W.; Nolte, Roeland J. M. published the article 《Enantioselective synthesis of chiral porphyrin macrocyclic hosts and kinetic enantiorecognition of viologen guests》. Keywords: chiral porphyrin preparation enantioselective kinetic enantiorecognition viologen guest.They researched the compound: (S)-Butan-2-ol( cas:4221-99-2 ).Related Products of 4221-99-2. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:4221-99-2) here.

The asym. synthesis of two enantiomeric C2-sym. porphyrin macrocyclic hosts (R,R,R,R)/(S,S,S,S)-I that thread and bind different viologen guests is described. Time-resolved fluorescence studies show that these hosts display a factor 3 kinetic preference (ΔΔGon = 3 kJ mol-1) for threading onto the different enantiomers of a viologen guest appended with bulky chiral 1-phenylethoxy termini. A smaller kinetic selectivity (ΔΔGon = 1 kJ mol-1) is observed for viologens equipped with small chiral sec-butoxy termini. Kinetic selectivity is absent when the C2-sym. hosts are threaded onto chiral viologens appended with chiral tails in which the chiral moieties are located in the centers of the chains, rather than at the chain termini. The reason is that the termini of the latter guests, which engage in the initial stages of the threading process (entron effect), cannot discriminate because they are achiral, in contrast to the chiral termini of the former guests. Finally, the experiments show that the threading and de-threading rates are balanced in such a way that the observed binding constants are highly similar for all the investigated host-guest complexes, i.e. there is no thermodn. selectivity.

Compounds in my other articles are similar to this one((S)-Butan-2-ol)Related Products of 4221-99-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《p-Mentha-1,5,8(9)-triene and its pyrolysis to dehydroocimene》. Authors are Alder, Kurt; Schumacher, Marianne.The article about the compound:(2-Methylthiazol-4-yl)methanolcas:76632-23-0,SMILESS:OCC1=CSC(C)=N1).Application of 76632-23-0. Through the article, more information about this compound (cas:76632-23-0) is conveyed.

LiAlH4 reduction of d(+)-carvone (I) gives 90% d-cis-carveol (II) which is dehydrated to p-mentha-1,5,8(9)-triene (III) whose structure is established, and which, on pyrolysis, gives 2,6-dimethyl-1,3,5,7-octatetraene (IV), called dehydroocimene. I (90 g.) in about 150 cc. ether added dropwise to 7.5 g. LiAlH4 in ether, warmed 1 hr., extracted with H2O then dilute H2SO4, and the ether layer evaporated and distilled gives carveol, b13 111-12°, which, distilled over KHSO4 in vacuo to 100° to remove volatile matter, leaves a residue which fractionated gives 60-5 g. III, b14 65-6.5°, nD20 1.4883, d20 0.8656, MR 44.69, λ 262 mμ (log ε 3.481). Ozonization of III in EtOAc gives CH2O in good yield. III with H and PtO2 takes up 6 H atoms/mole to give p-menthane, or warmed with 5% HCl in AcOH gives a quant. yield of p-cymene. III (6.5 g.) heated 15 hrs. in bomb with over 2 moles/mole III of di-Me acetylenedicarboxylate in 10 cc. PhMe at 140°, the product b0.04 90-120°, saponified and recrystallized from EtOAc gives the insoluble 3,6-dihydro-4-methyl-o-phthalic acid, m. 216°, and the soluble 4-methyl-o-phthalic acid, m. 159°, in equal amounts III adds to maleic anhydride in ether to give the adduct (V), m. 89-90°, whose hydrogenated derivative (VI), m. 91-2°, does not give CH2O on ozonization. V with 50% H2SO4 in dioxane 2-3 days gives a solution which extracted with ether gives the monolactone (VII), m. 184-5°; Me ester (VIII), m. 128-9°. Ozonization of VII in EtOAc gives acetone and an oxo acid, m. 215°; Me ester, m. 168°. VIII boiled with 10% NaOEt and the chief product lactonized with 50% H2SO4 in dioxane gives the dilactone (IX), m. 158°. The di-Me ester of V with 10% NaOEt gives a trans acid, m. 256°, whose dilactone, m. 164-5°, is not identical with IX. III (8 g.) refluxed 6-7 hrs. with 7 g. α-naphthoquinone in 15 cc. C6H6, the C6H6 removed, and the residue extracted with MeOH gives 80-90% adduct (X), m. 90-1°. Aeration of X in hot MeOH and alc. KOH gives an oil which boiled with EtOH gives 2-methylanthraquinone, m. 174-5°, and isoprene. Pyrolysis of III (105 g.) by distilling it at 12 mm. through a 75-cm. quartz tube at 520-40° at such a rate as to give one drop cracking product/sec. gives a hydrocarbon mixture which, redistilled in an N atm. at 36-72°/13 mm., gives mostly IV, nD20 1.4959, d20 0.8671, λ 303 mμ (log ε 3.934). IV is easily cyclized to p-cymene by distillation or by treatment with iodine in C6H6. IV (80 g.) in 100 cc. ether under N treated with 50 g. maleic anhydride 12 hrs. at room temperature, the unreacted IV removed by distillation, the residue taken up in Na2CO3 solution, extracted with ether, and acidified gives the ether-soluble adduct (XI), m. 191°. Ozonization of XI gives acetaldehyde while dehydrogenation of 2.5 g. XI with 0.8 g. S at 200° followed by extraction with Na2CO3 solution and acidification give 4,7-dimethylnaphthalene-1,2-dicarboxylic acid (XII), m. 213-14°; anhydride, m. 235-6°. Oxidation of 0.5 g. XII with 3 cc. HNO3 (d. 1.4) 16 hrs. at 140° in bomb followed by reaction with CH2N2 gives C6H(CO2Me)5, m. 147-8°. XI (1.2 g.) in CHCl3 with Br gives HBr and needles of C14H16O4Br2, m. 233°. Catalytic hydrogenation of XI in AcOH adds 1 mole H to give C14H20O4, m. 177-8°, which can be dehydrogenated by S to XII. Oxidation of XI by alk. KMnO4 gives a product of unknown constitution, C14H18O7, m. 282° (decomposition). IV (8 g.) refluxed 5-6 hrs. in C6H6 with 7 g. α-naphthoquinone, the C6H6 removed, and the residue recrystallized from MeOH gives a nearly quant. yield of adduct (XIII), needles, m. 115-16°. Dehydrogenation of XIII by air in 17% alc. KOH gives yellow needles of C20H16O2 (XIV), m. 145-6°. XIV is oxidized by HNO3 at 200° to give an acid which with CH2N2 gives tri-Me anthraquinone-1,2,3-tricarboxylate, m. 184-5°. Dehydrogenation of XIV by S at 190° gives 2′,3-dimethyl-1,2-benzanthraquinone (XV), m. 205°. XV is reduced by Zn and acetylated to C24H20O4, m. 175-6°, which is again oxidized by air in alc. KOH to XV. Addition of IV to di-Me acetylenedicarboxylate in C6H6, warming 3-4 hrs., and distilling give an ester, C16H18O4, m. 118-19°, whose saponification with alc. KOH gives an acid, m. 213-14°, which heated gives the anhydride, m. 197-8°, and which dehydrogenated with S and then boiled with acetic anhydrous gives 4,7-dimethylnaphthalene-1,2-dicarboxylic anhydride, m. 235-6°.

Compounds in my other articles are similar to this one((2-Methylthiazol-4-yl)methanol)Application of 76632-23-0, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Formula: C5H4BrN5O. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Kinetics and mechanism of plasmon-driven dehalogenation reaction of brominated purine nucleobases on Ag and Au. Author is Dutta, Anushree; Schuermann, Robin; Kogikoski, Sergio Jr.; Mueller, Niclas S.; Reich, Stephanie; Bald, Ilko.

Plasmon-driven photocatalysis is an emerging and promising application of noble metal nanoparticles (NPs). An understanding of the fundamental aspects of plasmon interaction with mols. and factors controlling their reaction rate in a heterogeneous system is of high importance. Therefore, the dehalogenation kinetics of 8-bromoguanine (BrGua) and 8-bromoadenine (BrAde) on aggregated surfaces of silver (Ag) and gold (Au) NPs have been studied to understand the reaction kinetics and the underlying reaction mechanism prevalent in heterogeneous reaction systems induced by plasmons monitored by surface enhanced Raman scattering (SERS). We conclude that the time-average constant concentration of hot electrons and the time scale of dissociation of transient neg. ions (TNI) are crucial in defining the reaction rate law based on a proposed kinetic model. An overall higher reaction rate of dehalogenation is observed on Ag compared with Au, which is explained by the favorable hot-hole scavenging by the reaction product and the byproduct. We therefore arrive at the conclusion that insufficient hole deactivation could retard the reaction rate significantly, marking itself as rate-determining step for the overall reaction. The wavelength dependency of the reaction rate normalized to absorbed optical power indicates the nonthermal nature of the plasmon-driven reaction. The study therefore lays a general approach toward understanding the kinetics and reaction mechanism of a plasmon-driven reaction in a heterogeneous system, and furthermore, it leads to a better understanding of the reactivity of brominated purine derivatives on Ag and Au, which could in the future be exploited, for example, in plasmon-assisted cancer therapy.

Compounds in my other articles are similar to this one(8-Bromoguanine)Formula: C5H4BrN5O, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Mechanism of the antagonistic action of xanthine derivatives against adenosine and coronary vasodilators, published in 1972, which mentions a compound: 1028-33-7, Name is 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, Molecular C13H20N4O2, SDS of cas: 1028-33-7.

The coronary dilating activity of adenosine (I) [58-61-7], dipyridamole (II) [58-32-2], and lidoflazine (III) [3416-26-0] in anesthetized dogs was inhibited by 1-substituted xanthines, e.g. caffeine (IV) [58-08-2] or theophylline (V) [58-55-9], provided the substituent was small and no substituent was present at the 7 position. The enhancement of the coronary dilating activity of I by II and III was not inhibited by IV or V. The suppression of I permeation through erythrocyte membranes caused by II or III was not reversed by V. The coronary vasodilation induced by carbocromene [804-10-4], which did not suppress the I permeation through erythrocyte membranes, was not influenced by IV or V, indicating a different mode of action.

Compounds in my other articles are similar to this one(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)SDS of cas: 1028-33-7, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Product Details of 51856-79-2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate, is researched, Molecular C8H11NO2, CAS is 51856-79-2, about Synthesis and antifungal activity of some new 1,2,4-triazole and furan containing compounds. Author is Shehata, Ihsan A..

Several new 1,2,4-triazole analogs attached to substituted Ph, pyrrole or furan 5-membered heterocycles were synthesized and screened for their antimicrobial activity. Bromination of Me 2-methylfuran-3-carboxylate, followed by ring closure with aniline, gave 5,6-dihydro-4-oxo-5-phenyl-4H-furo[2,3-c]pyrrole (I) in 55% yield (two steps). Compounds I and 3-(1-methyl-2-pyrrolylmethyl)-4-phenyl-5-(4-chlorophenylcarbamoylmethylthio)-1,2,4-triazole showed a prominent activity against C. albicans and S. cerevisiae.

Compounds in my other articles are similar to this one(Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetate)Product Details of 51856-79-2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

Name: (S)-Butan-2-ol. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: (S)-Butan-2-ol, is researched, Molecular C4H10O, CAS is 4221-99-2, about Time-space-resolved origami hierarchical electronics for ultrasensitive detection of physical and chemical stimuli.

Recent years have witnessed thriving progress of flexible and portable electronics, with very high demand for cost-effective and tailor-made multifunctional devices. Here, we report on an ingenious origami hierarchical sensor array (OHSA) written with a conductive ink. Thanks to origami as a controllable hierarchical framework for loading ink material, we have demonstrated that OHSA possesses unique time-space-resolved, high-discriminative pattern recognition (TSR-HDPR) features, qualifying it as a smart sensing device for simultaneous sensing and distinguishing of complex phys. and chem. stimuli, including temperature, relative humidity, light and volatile organic compounds (VOCs). Of special importance, OSHA has shown very high sensitivity in differentiating between structural isomers and chiral enantiomers of VOCs – opening a door for wide variety of unique opportunities in several length scales.

Compounds in my other articles are similar to this one((S)-Butan-2-ol)Name: (S)-Butan-2-ol, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The effect of the position of chiral (-)-menthyl on the formation of blue phase and mesophase behavior in biphenyl-benzoate liquid crystals, published in 2020-01-15, which mentions a compound: 77341-67-4, mainly applied to menthyloxyoxoalkanoyloxy biphenylylbutoxybenzoate preparation crystal structure, Electric Literature of C14H24O4.

Eight new chiral liquid crystal compounds 4-(4-menthyloxy-n-oxoalkanoyloxy)biphenyl-4′-yl 4-butoxybenzoates I [n = 1, 2, 3, 4, etc.], were prepared by modifying the position of chiral (-)-menthyl in the menthol based liquid crystal compounds through gradually increasing the alkyl chain length of the dicarboxylic spacer. All compounds were characterized by FT-IR and NMR spectroscopy in order to prove their chem. structures. Differential scanning calorimetry (DSC), polarized optical microscopy (POM) and X-ray diffraction were carried out to systematically investigate their phase transition behaviors. The position of chiral (-)-menthyl in relation to the core effected on the formation of BPs and mesomorphic behaviors. Only CLCs I [n = 1, 2] with short spacer chains presented blue phases. Furthermore, the length and parity of the flexible spacers showed profound influence on phase structures and phase transition behaviors. An odd-even effect was observed for these chiral liquid crystal compounds

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Electric Literature of C14H24O4, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Inhibition of various cyclic AMP phosphodiesterases by pentifylline and theophylline》. Authors are Stefanovich, V.; Von Poelnitz, M.; Reiser, M..The article about the compound:1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dionecas:1028-33-7,SMILESS:CN1C=NC(N(C(N2CCCCCC)=O)C)=C1C2=O).Formula: C13H20N4O2. Through the article, more information about this compound (cas:1028-33-7) is conveyed.

The inhibiting effect of pentifylline (1-hexyl-3,7-dimethylxanthine) (I) and theophylline (II) was tested on 3′,5′-AMP-phosphodiesterase (III) of 7 organs of guinea pigs, of rat brain, and bovine heart. I was a better inhibitor than II of III of rat brain and bovine heart. The difference between the degrees of inhibition by I and II was largest in the case of III of rat brain. I inhibited III of bovine heart noncompetitively and II did so competitively. Serum albumin affected the I inhibition of bovine heart III more than it did the inhibition by II. II exhibited the highest effect on guinea pig heart III while I did so on III of brain.

Compounds in my other articles are similar to this one(1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione)Formula: C13H20N4O2, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem

So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Koseki, Yoshitaka; Ikuta, Yoshikazu; Cong, Liman; Takano-Kasuya, Mayumi; Tada, Hiroshi; Watanabe, Mika; Gonda, Kohsuke; Ishida, Takanori; Ohuchi, Noriaki; Tanita, Keita; Taemaitree, Farsai; Dao, Anh Thi Ngoc; Onodera, Tsunenobu; Oikawa, Hidetoshi; Kasai, Hitoshi researched the compound: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid( cas:77341-67-4 ).Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid.They published the article 《Influence of Hydrolysis Susceptibility and Hydrophobicity of SN-38 Nano-Prodrugs on Their Anticancer Activity》 about this compound( cas:77341-67-4 ) in Bulletin of the Chemical Society of Japan. Keywords: prodrug SN38 hydrophobicity cancer antitumor. We’ll tell you more about this compound (cas:77341-67-4).

In the field of drug delivery, controllability of drug release site and duration are among the most important factors to manipulate the drug efficacy and side effects. In this paper, a series of nano-prodrugs (NPs) composed of anticancer agent SN-38 and various substituent groups were synthesized and fabricated. By increasing the hydrophobicity of the prodrug mol. (calculated logP values exceeded ca. 7) through changing the substituent group, the hydrolysis susceptibility of SN-38 NPs in mouse serum was drastically decreased, thus prolonged the blood retention time of the NPs. In light of this knowledge and the dispersion stability in aqueous media, SN-38 NP modified with cholesterol (SN-38-chol NPs) was selected to be the optimal candidate among the screened NPs. The in vivo pharmacol. effect of SN-38-chol NP was about 10 times higher than irinotecan, the clin. used solubilized prodrug analog of SN-38. In addition, SN-38-chol NP has low side effects in evaluating intestinal damage. These NPs possess great potential for clin. application and promise to be a next-generation of drug for cancer treatment.

Compounds in my other articles are similar to this one(4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid)Name: 4-(((1R,2S,5R)-2-Isopropyl-5-methylcyclohexyl)oxy)-4-oxobutanoic acid, you can compare them to see their pros and cons in some ways,such as convenient, effective and so on.

Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem