Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about The reaction of nucleic acids with bromine.Synthetic Route of C5H4BrN5O.
Com. preparations of ribonucleic acid (RNA) from yeast and of deoxyribonucleic acid (DNA) from sperm, as well as high mol. DNA isolated from thymus reacted in aqueous solution with Br at temperature down to -35°. The mol. weight of brominated RNA decreased by about 15%. The nucleic acids were hydrolyzed in 70% HClO4. Paper chromatography of the products revealed the presence of 5-bromouracil, 5-bromocytosine and 8-bromoguanine. There was no indication that Br reacted with adenine or with the pentoses. Ribonuclease attacked the brominated products in the same way as normal RNA. Ultraviolet spectra of Brcontg. acids differed slightly from the original material, but infrared spectra in the range of 6.3-7.3 μ were markedly different.
In some applications, this compound(3066-84-0)Synthetic Route of C5H4BrN5O is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem