Product Details of 3066-84-0. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: 8-Bromoguanine, is researched, Molecular C5H4BrN5O, CAS is 3066-84-0, about Development of antischistosomal agents: inhibitors of hypoxanthine-guanine phosphoribosyltransferase. Author is Jadhav, Arun L.; Sirossian, Shahrokh.
Derivatives of purines and 5-phosphoribosyl 1-pyrophosphate (PRPP), substrates for purine salvage enzymes, were tested for their ability to inhibit hypoxanthine-guanine phosphoribosyltransferase (HPRT, E.C. 2.4.2.8) isolated from Schistosoma mansoni in vitro. The parasite enzyme exhibited different kinetic characteristics than the human enzyme. The C2- and C6-substituted purine derivatives, as well as PRPP-polyamine complexes, were found to be active against the enzyme. An intact purine ring appeared to be necessary for the activity against the hypoxanthine-dependent reactions mediated by the parasite enzyme, since benzimidazoles, quinolines, and triazoles were found to be inactive. Addnl., it appeared that PRPP-polyamine complexes which inhibit the PRPP-dependent reaction may provide a novel approach to new chemotherapeutics agents for schistosomiasis.
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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem