SDS of cas: 1028-33-7. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 1-Hexyl-3,7-dimethyl-1H-purine-2,6(3H,7H)-dione, is researched, Molecular C13H20N4O2, CAS is 1028-33-7, about Comparative intestinal absorption of a series of xanthines in aqueous or oil solutions. Author is Nook, T.; Doelker, E.; Buri, P..
The intestinal absorption of a group of xanthines from oil solutions was tested in rats by means of an in situ perfusion technique. Tributyrin [60-01-5], tricaprylin [538-23-8], and Et laurate [106-33-2] were used as lipid vehicles able to increase the absorption of these drugs. For this series of xanthine derivatives, absorption was higher from oil solutions than from Sorensen buffer when the drug partition coefficient was <1. Although the affinity of the drugs for the vehicle was related to the absorption profiles, this could not explain all the absorption results. There was strong evidence that the nature of the oil plays concomitantly an important role. This was particularly the case for Et laurate, which highly increased the intestinal absorption of theophylline [58-55-9]. Measurements of the appearance of this drug in the rat blood confirmed the favorable effect of this vehicle. Theophylline was further perfused as a suspension in Et laurate in order to test the effects of a higher drug-to-oil ratio. In this case, absorption from the oil suspension was of the same extent as an aqueous solution of identical concentration This seems to indicate that Et laurate may also affect the solubilization of the solid drug. When you point to this article, it is believed that you are also very interested in this compound(1028-33-7)SDS of cas: 1028-33-7 and due to space limitations, I can only present the most important information.
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Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem