Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Youji Huaxue called Synthesis (2E)-2-methyl-3-(2-methyl-4-thiazolyl)-2-propenethioic acid S-[2-(acetylamino)ethyl] ester and 2-methyl-4-thiazolecarbothioic acid S-[2-(acetylamino)ethyl] (modified intermediates for epothilone biosynthesis), Author is Sun, He; Hu, Wei; Wang, Zong-Heng; Li, Yue-Zhong; Zhao, Gui-Long; Wang, Jian-Wu, which mentions a compound: 76632-23-0, SMILESS is OCC1=CSC(C)=N1, Molecular C5H7NOS, Safety of (2-Methylthiazol-4-yl)methanol.
Methods for the synthesis of the title compounds [i.e., (2-methyl-4-thiazolyl)carboxylic [2-(acetamido)ethyl]thiol thioester and (E)-2-methyl-3-(2-methyl-4-thiazolyl)acrylic [2-(acetamido)ethyl]thiol thioester] are reported here. In order to investigate the biosynthesis of epothilones and generate novel biosynthetic epothilone analogs by a precursor-directed biosynthesis, two modified intermediates for epothilone biosynthesis were designed and synthesized. The new synthetic procedures utilized are inexpensive and convenient. The structures of these compounds were confirmed by IR, MS, 1H NMR and 13C NMR spectra and elemental anal.
As far as I know, this compound(76632-23-0)Safety of (2-Methylthiazol-4-yl)methanol can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem