In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called The two faces of the guanyl radical: molecular context and behavior, published in 2021, which mentions a compound: 3066-84-0, mainly applied to review guanyl radical two face mol context behavior; DNA; G-quadruplex; guanine; guanine radical cation; guanyl radical; oligonucleotides; oxidation; reactive oxygen species (ROS); tautomerism; time-resolved spectroscopies, Safety of 8-Bromoguanine.
A review. The guanyl radical or neutral guanine radical G(-H)• results from the loss of a hydrogen atom (H•) or an electron/proton (e-/H+) couple from the guanine structures (G). The guanyl radical exists in two tautomeric forms. As the modes of formation of the two tautomers, their relationship and reactivity at the nucleoside level are subjects of intense research and are discussed in a holistic manner, including time-resolved spectroscopies, product studies, and relevant theor. calculations Particular attention is given to the one-electron oxidation of the GC pair and the complex mechanism of the deprotonation vs. hydration step of GC•+ pair. The role of the two G(-H)• tautomers in single- and double-stranded oligonucleotides and the G-quadruplex, the supramol. arrangement that attracts interest for its biol. consequences, are considered. The importance of biomarkers of guanine DNA damage is also addressed.
As far as I know, this compound(3066-84-0)Safety of 8-Bromoguanine can be applied in many ways, which is helpful for the development of experiments. Therefore many people are doing relevant researches.
Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem