The reaction of an aromatic heterocycle with a proton is called a protonation. One of articles about this theory is 《Synthesis, antimicrobial, and anti-inflammatory activities of acetamido pyrrolyl azoles》. Authors are Sowmya, Donthamsetty V.; Basha, Shaik Sharafuddin; Devi, Palampalli Uma Maheswari; Lavanyalatha, Yerraguravagari; Padmaja, Adivireddy; Padmavathi, Venkatapuram.The article about the compound:Methyl 2-(1-methyl-1H-pyrrol-2-yl)acetatecas:51856-79-2,SMILESS:O=C(OC)CC1=CC=CN1C).Computed Properties of C8H11NO2. Through the article, more information about this compound (cas:51856-79-2) is conveyed.
Series of 2-(pyrrol-2-yl)-N-(oxazol-2-yl)acetamides I [R = H, Me, MeO, Cl, Br, NO2; X = O], 2-(pyrrol-2-yl)-N-(thiazol-2-yl)acetamides I [X = S] and 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [X = NH] were prepared via reaction of (5-benzoyl-1-methyl-1H-pyrrol-2-yl)acetic acid with 4-aryloxazol-2-amines/4-arylthiazol-2-amines/4-aryl-1H-imidazol-2-amines resp. All the synthesized compounds I were screened for their antibacterial, antifungal and anti-inflammatory activities. Among the tested compounds, 2-(pyrrol-2-yl)-N-(thiazol-2-yl)acetamides I [R = NO2; X = S] and 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [R = NO2; X = N] exhibited promising antibacterial activity against K. pneumoniae. The 2-(pyrrol-2-yl)-N-(imidazol-2-yl)acetamides I [R = NO2; X = N] showed good antifungal activity against P. chrysogenum and 2-(pyrrol-2-yl)-N-(oxazol-2-yl)acetamidesI [R = MeO; X = O] displayed potential anti-inflammatory activity.
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Reference:
Tetrahydrofuran – Wikipedia,
Tetrahydrofuran | (CH2)3CH2O – PubChem